Talk:TRAIL

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Questions

Latest comment: 8 years ago2 comments2 people in discussion

Which cells produce TRAIL, and under what circumstances?
Does TRAIL act on the receptors of the cell that produced it, or on some other cell?
Is TRAIL a transmembrane protein, or is it released into the extracellular fluid? (The article states that it has "characteristics of a transmembrane protein".)

Identification and characterization of a new member of the TNF family that induces apoptosis. says " TRAIL is a type II membrane protein, whose C-terminal extracellular domain shows clear homology to other TNF family members. TRAIL transcripts are detected in a variety of human tissues, most predominantly in spleen, lung, and prostate." - Rod57 (talk) 14:27, 17 February 2016 (UTC)Reply