Talk:Tardive dyskinesia

Thanks for the heads up.

I suffered three severe bouts which nearly killed me when my tongue swelled, and my neck and throat muscles went into a tonic spasm.

I apparently suffer massive twitching bouts in my sleep, three years on. Thanks for the info.--218.215.195.80 06:22, 30 August 2006 (UTC)

MUST ??

"The devastating impact of tardive dyskinesia illustrates why patients and/or their families (guardians and/or caregivers/nurses) must receive full information about the neuroleptic before starting treatment (informed consent)."

I rewrote to " Some believe the devastating impact of tardive dyskinesia illustrates why patients and/or their families (guardians and/or caregivers/nurses) should receive full information about the neuroleptic before starting treatment (informed consent)."

Feel free to revert, it just struck me as an opinion, even if it is one I agree with! DisneyFreak96 20:18, 26 October 2006 (UTC)

Pharmacogenetics of Tardive Dyskinesia

I've just read a Medscape article "Pharmacogenetics and Psychotropic Drugs" (2000) by Takuya Saito. It has an interesting subsection on the frequency of TD in patients with different alleles in two genes: for the D3 receptor and for CYP1A2.

Medscape demands a free registration to read its articles, so I quote:

"Gene Polymorphisms and Tardive Dyskinesia (TD)

A recent study published in Molecular Psychiatry [2] points out that genetic make-up in individuals may contribute to predisposition to side effects. Pharmacodynamics (ie, how a medication affects the body) and pharmacokinetics (ie, how the body metabolizes a medication) are influenced by genes. Kennedy and others[3] studied 2 genes and their association with TD. One gene is dopamine D3 receptor, which involves pharmacodynamics of antipsychotics. The other is CYP1A2, which involves pharmacokinetics of antipsychotics.

Kennedy studied 248 schizophrenia patients diagnosed by the Diagnostic and Statistical Manual of Mental Disorders, third edition, revised (DSM-III-R), and he and his associates evaluated the severity of TD using the abnormal involuntary movement scale (AIMS) 2 weeks after typical antipsychotics were discontinued. An association study was conducted using an SNP, which changes an amino acid from ser to gly. In Ser/ser genotype, AIMS was 3.47. In ser/gly, AIMS was 3.92. In gly/gly, AIMS was 14.20. There was a statistical significance between the D3 receptor polymorphism and AIMS (F[2,95]=8.25, P < .0005), and gly/gly genotype was associated with high AIMS score. The study group also investigated an association between CYP1A2 and TD. There is an SNP (C->A change) in first intron of CYP1A2 gene, which affects the gene expression of CYP1A2. In the same sample, in A/A genotype, AIMS was 5.2. In A/C genotype, AIMS was 6.6. In C/C genotype, AIMS was 17.8. There was statistical significance between the CYP1A2 polymorphism and AIMS (F[2,82] = 7.41, P < .0007), and C/C genotype was associated with high AIMS score. Kennedy and colleagues also conducted association studies using dopamine D2, D4 polymorphisms, and CYP2D6 polymorphisms, but they did not find any association. They also tested interaction between the dopamine D3 polymorphism and the CYP2D6 polymorphism toward TD. They found that these 2 polymorphisms had an additive effect for TD. These findings have been replicated, and SNPs may have benefit to predict potential side effects from medications."

Maybe we should include the "pharmacogenetics" section in the article and fill it with appropriate information? --CopperKettle 14:23, 27 November 2006 (UTC)

Long-term condition

i disagree Tardive Dyskinesia is a long term condition

i was in a mental hospital for a few days

shortly after release the cogentin was no longer working but the thorazine was

i developed tardive dyskinesia for a few days

my tongue was stuck out

and it was difficult to talk

Festus Christopher King (fcking2000@yahoo.com)

That would be an extra-pyramidal effect, not tardive. Midgley 23:33, 23 March 2006 (UTC)

I'm taking a Psych Nursing class at the moment. Based on that and what Wiki has to say about Extrapyramidal Symptoms (EPS), Tardive Dyskinesia IS an EPS. -- Nick

I have moved this comment thread into a topic. It was located at the top of the page. JMPZ 01:37, 5 April 2007 (UTC)

Sorry, you are incorrect. The person above was referring to a dystonic reaction, which is a short-term (meaning it appears within hours/days) side effect of many serotonin and dopamine agonist drugs (aka "antipsychotics"). Tardive dyskinesia is a delayed response which has a different (though related) pathophysiology. —Preceding unsigned comment added by 68.149.145.163 (talk) 09:33, 23 April 2008 (UTC)

Introduction could be more concise, on-topic

The introduction provides plenty of information about what drugs cause tardive dyskinesia, as well as which types of drugs are better or worse than others.

This information should probably be moved below the contents links. After reading the introduction, I knew what caused the symptoms, but not what the symptoms were. The introduction should contain a summary / overview of the symptoms and what causes them (but not a discussion of which neuroleptics cause it to what degree). JMPZ 01:37, 5 April 2007 (UTC)

For example, what on earth is this statement doing in the introduction? "The use of MDMA (ecstasy) has been shown to enhance the effects of L-Dopa while reducing the associated dyskinesia in primates with simulated Parkinson's disease." JMPZ 02:16, 5 April 2007 (UTC)

About 5% year-by-year increase in TD

I've added a ref (PMID 8100643) supporting that statement. Just was reading a case story in JAMA and stumbled upon a similar statement with citations:

Tardive dyskinesia occurs with a frequency of approximately 5% per year of exposure to conventional neuroleptics and is not dose-related.(62) Elderly individuals have much higher rates of adverse neurological effects, including a 30% incidence of tardive dyskinesia during the first year of exposure.(63)

Still not sure about the "no upper limits" though. Best regards, CopperKettle 05:59, 8 April 2007 (UTC)

Increasing dose

I've read that increasing the dose of the neuroleptic actually reduces tardive dyskinesia. I guess this is because the syndrome is caused by a sensitization of dopamine receptors? Maybe increasing the dose overcomes the sensitization, reducing symptoms? Anyone else heard about this?

I haven't heard about that. However, I would be interested in reading a source about it. Neitherday 23:18, 12 April 2007 (UTC)

In response to your question regarding increasing Neuroleptics to decrease TD, this is what I have read about it. "...increasing conventional neuroleptic dosage increases the risk and severity of tardive dyskinesia in the long run..." taken from the following website Hello, World. {{1. Priory.com}} {{2. http://priory.com/tardive-dyskinesia.htm}} Looks like this needs to be done with caution. Singer51781 (talk) 03:46, 20 April 2012 (UTC)singer51781

References

introduction

I removed this: "Year-long implants that are being developed using the older typicals[citation needed], e.g., haloperidol, one of the worst offenders when it comes to tardive dyskinesia[citation needed]. " because it's ungrammatical and hence meaningless. I can think of at least three very different things it might be trying to express, depending on how you fix the grammar. Anyone who likes this bit should turn it into an ACTUAL SENTENCE and have a think about whether it means what they want it to mean. --snaxalotl 20 july 2007

"only clozapine has been shown to have a lower risk of tardive dyskinesia than older antipsychotics" this seems to be unnecessarily absolute for a statement sourced from a textbook. I think there might be a couple of papers suggesting otherwise for Quetiapine, for example

The Dark Knight

Is it me... or is the Joker portrayed to have Tardive dyskinesia?--68.102.139.94 (talk) 08:32, 19 July 2008 (UTC)

It would appear so. Lysergic milkman (talk) 06:37, 15 December 2009 (UTC)

What was wrong with me?

This past Friday night I took some Geodon (120mg) and the next day I suffered the most horrifying side effect of a drug in my life. My whole head literally wouldn't stop twisting to the FAR left. I had no control over this ridiculous movement. I'm just now starting to feel better, and I took the pill over 2 days ago. Does this sound like TD, or something related?

No, that sounds like acute (drug-induced) cervical dystonia. It is a common side-effect with Geodon. Refer yourself to the wiki page on dystonia for more detailed information. Lysergic milkman (talk) 06:37, 15 December 2009 (UTC)

"tardive" poorly/incorrectly defined

The following paragraph is found in the introduction to this page: "The term tardive dyskinesia was introduced in 1964. Dyskinesia refers to an involuntary movement. The effect of these drugs can be tardive, meaning the dyskinesia sometimes continues or appears even after the drugs are no longer taken."

Tardive means "a delayed or late onset," which refers to the time after a drug is ingested but before the condition occurs, not the propensity for the condition to continue after the drug has been ingested.

Aside from the syntax error (the term used to describe the wrong object entirely), the term itself is incorrectly defined, leading one to believe that tardive dyskinesia means "permanent, uncontrollable muscle movements." While the condition usually IS indeed permanent, that affect is not implied by the terminology. Lysergic milkman (talk) 06:37, 15 December 2009 (UTC)

Yi-Gan San

There is a study on Yi gan san in a japanese study conducted by psychiatrists at a medical school, involving roughly 24 subjects. It showed yi gan san reduced the tardive dyskinesia symptoms after being taken. It also reduced psychosis, for those with schizophrenia. The AIMS score decreased by 90% on average. Abnormal Involuntary Movement Scale. Please google tardive dyskinesia and yi gan san. I have access to the study if anyone wants to look at it. I have never edited before on wikipedia, so I am not comfortable editing the section yet. I will look back for any guidance. Any help would be appreciated. —Preceding unsigned comment added by 76.122.99.157 (talk) 00:20, 7 February 2010 (UTC)

Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study. abstract on Pubmed. Gaba amine (talk) 04:59, 12 May 2012 (UTC)

Mid Priority

Can this article also be rated a Mid priority. It affects around 70% percent of schizophrenics and a significant portion of bipolar disorder people. It would be an important article to get reviewed. Something that affects around 2-3% of the population is not a small matter. —Preceding unsigned comment added by 76.122.99.157 (talk) 00:25, 7 February 2010 (UTC)

Tardive dyskinesia potentially fatal?

Regarding sentence: "Tardive dyskinesia (pronunciation) is an incurable, potentially fatal variety of dyskinesia[1] (involuntary, repetitive movements) manifesting as a side effect of long-term or high-dose use of dopamine antagonists, usually antipsychotics."

It is true that this disease is incurable, but in some patients the disorder resolves immediately or over time upon cessation of the neuroleptic or antiemetic medication. Additionally, tardive dyskinesia itself is NOT "potentially" FATAL. Neuroleptic malignant syndrome that is caused from the suspect drug can be fatal; however tardive dyskinesia itself is NEVER fatal. Neuroleptic malignant syndrome, if caught by a physician, in many cases can be remedied by cessation of the drug that is causing it.

Before I change this, I would like someone to concur with my findings through their own research. Of course any change would be backed up by citations to authoritative sources. —Preceding unsigned comment added by Jason.guard (talk • contribs) 21:15, 15 March 2010 (UTC)

I'm watching the 1983 PBS documentary Children of Darkness, which includes a kid who died from Tardive Dyskinesia at South Beach Psychiatric Center on Staten Island, so the answer is yes. ---------User:DanTD (talk) 07:30, 26 February 2020 (UTC)

I'm mighty curious to hear HOW it killed him.--Quisqualis (talk) 05:47, 28 February 2020 (UTC)

It causes you to lose control of your body, including biting your tongue against your will, like it did with the third kid at South Beach in the documentary. It can also cause your throat to inflate to the point where it's so thick that you can't breathe, lose control of your fingers, toes, hands, arms, legs, feet, your torso and other parts. And you don't really have to be schizophrenic of bipolar for this to happen either. ---------User:DanTD (talk) 18:43, 4 March 2020 (UTC)

infobox figure

When I initially brought up the article I was confused since I saw a pic of dopamine in the infobox with the title "tardive dyskinesia". Surely the picture isn't tardive dyskinesia, it's dopamine. Do people normally 100% associate dopamine with tardive dyskinesia, or tardive dyskinesia with dopamine, and is that connection conclusive and correct? Should the picture in the infobox be changed to one that is more indicative of tardive dyskinesia, or should the title be changed to dopamine? I only bring this up since it looks like someone did change the title to dopamine (past revisions of this article), but it was changed back to tardive dyskinesia... --98.70.57.187 (talk) 18:22, 14 November 2010 (UTC)

glycine and other NMDA receptor modulators and TD

"New classes of antipsychotics in study such as glycine and other NMDA receptor modulators in not affecting the dopaminergic system in Phase II FDA studies have been shown not to cause tardive dyskinesia and may, once realized as FDA approved antipsychotics, be a new treatment modality that will not create this condition.[citation needed]" I suppose we erase this; both therapeutic method are so new and it takes a time to find these side effects, so we cannot seriously claim that. --79.138.33.224 (talk) 19:16, 14 December 2011 (UTC)

Article quality

There are too many uncited statements in this article. A scientific article shouldn't contain any statements unsupported by suitable citations. In particular, the section on epidemiology is degenerating into a series of contradictory statements without citations. In a short while, I intend to remove any uncited statements; if corect, they can be replaced with suitable citations. In the meantime I suggest existing contributors add citations to anything they wish to be retained. Dubbin^u | t 10:42, 17 January 2012 (UTC)

And I'll help. You're absolutely right about unsourced information. When do you want to start? — UncleBubba ^{( T @ C )} 15:41, 24 May 2012 (UTC)

Do not use brand names for drugs

Please use substance names for drugs in the treatment section as brand names are uninformative and commercial. I couldn't fix this because some bot reversed my actions. So someone who knows how to use this wikithing please do the changes.

89.166.119.215 (talk) 13:33, 24 May 2012 (UTC)

Tardive dystonia not permanent

The article says that tardive dystonia is permanent, but I think it lessens over months/years, depending on its severity. I myself have it from 5 weeks of 3 mg/day risperidone, it's been 9 months and the dystonia is significantly reduced, in another 2, to 4 years, there should be no sign of it. But my dystonia was not severe, I would imagine it could be practically permanent after a lengthier exposure to dopamine antagonists. — Preceding unsigned comment added by Broomattack (talk • contribs) 11:58, 24 August 2015 (UTC)

Don't be so sure of that. ---------User:DanTD (talk) 14:39, 23 July 2023 (UTC)