Talk:Timeline of aging research

Contested deletion

This page should not be speedily deleted because... this is not restoration of the previous article. What I do, is translation of the article of "Хронология исследования старения" from Russian wikipedia that what created independently (this is not reverse translation). I know that my English is not great (sorry) but I hope that some person soon clean up my grammatical bugs in the article. --Lady3mlnm (talk) 16:36, 4 May 2021 (UTC)

Items to add from the year in science articles and the need for ex/inclusion-criteria and/or layout changes

2019

• 22 August – Research by Norwegian scientists adds to a growing body of evidence that too much sitting is related to a higher risk of early death, and that even a small amount of regular activity can lengthen lifespan.
  • (I would not include that one)

• 16 September – Scientists at the Mayo Clinic report the first successful use of senolytics, a new class of drug with potential anti-aging benefits, to remove senescent cells from human patients with a kidney disease.

• 30 September – By combining doses of lithium, trametinib and rapamycin into a single treatment, researchers extend the lifespan of fruit flies (Drosophila) by 48%.

• 16 October – Researchers at Harvard Medical School identify a link between neural activity and human longevity. Neural excitation is linked to shorter life, while suppression of overactivity appears to extend lifespan.

• 13 November – Scientists in Japan use single-cell RNA analysis to find that supercentenarians have an excess of cytotoxic CD4 T-cells, a type of immune cell.

2020

• 4 March – Researchers report that their review indicates that the unguarded X hypothesis may be valid: according to this hypothesis one reason for why the average lifespan of males isn't as long as that of females – by 18% on average according to the study – is that they have a Y chromosome which can't protect an individual from harmful genes expressed on the X chromosome, while a duplicate X chromosome, as present in female organisms, can ensure harmful genes aren't expressed.
  • (I would not include that one)

• 16 July – Scientists report to have identified 10 genomic loci which appear to intrinsically influence healthspan, lifespan, and longevity – of which half have not been reported previously at genome-wide significance and most being associated with cardiovascular disease – as well as haem metabolism as a promising candidate for further research within the field. Their study using public biological data on 1.75 m people with known lifespans overall, suggests that haem metabolism may play a role in human ageing and that high levels of iron in the blood likely reduce, and genes involved in metabolising iron likely increase healthy years of life in humans.

• 10 July – Scientists report that after mice exercise their livers secrete the protein GPLD1, which is also elevated in elderly humans who exercise regularly, that this is associated with improved cognitive function in aged mice and that increasing the amount of GPLD1 produced by the mouse liver in old mice could yield many benefits of regular exercise for their brains – such as increased BDNF-levels, neurogenesis, and improved cognitive functioning in tests.
  • (This was removed from the list and simply nobody undid the removal.)

• 17 July – Scientists report that yeast cells of the same genetic material and within the same environment age in two distinct ways, describe a biomolecular mechanism that can determine which process dominates during aging and genetically engineer a novel aging route with substantially extended lifespan.

2021

• 20 January – Scientists report that the MOTS-c peptide in the mitochondrial genome is an AMPK-related regulator of age-dependent physical decline in mice and that its exogenous supply initiated in late-life can substantially increase their physical performance and healthspans.
  • (May not be fit for inclusion but should be discussed.)

• 20 January – Researchers report that myeloid cells are drivers of a maladaptive inflammation element of brain-ageing in mice and that this can be reversed or prevented via inhibition of their EP2 signalling.

• 4 May – Genetic signatures linked to extreme longevity in humans are identified by researchers and include genes for efficient DNA repair.
  • (There needs to be a Wiki-enabled database or so or at least a systematic review including many different studies rather than individual studies identifying such associations.)

• 17 May – The largest, UK Biobank-based, genome-wide association study of mitochondrial DNA unveils 260 new associations with phenotypes including lifespan and disease risks for e.g. type 2 diabetes.
  • (Same as above. However, both studies could still be relevant for inclusion "as is" here.)

• 25 May – The maximum lifespan for humans is placed at between 120 and 150, according to a longitudinal analysis of blood markers.
  • (I would not include that one)

Here are some items that I considered for inclusion in the year in science articles but found they may only be suitable for inclusion here:

• https://medicalxpress.com/news/2021-01-midlife-linked-brain-health-life.html
• https://medicalxpress.com/news/2021-04-anti-aging-compound-muscle-glucose-metabolism.html

Note that all very major items should probably also be included in their respective "year in science" articles.

---

I propose creating subsections for years starting with 2019 so that more items can be incorporated and the increased number of significant results are properly taken into consideration. Then this timeline could then also be added to this template (to Fields):

It would be good to start formalizing ex/inclusion criteria. One could also change the layout of the list to be a table and have categories for types of entries or importance. One of the advantages of this is that the list could then be sorted or filtered (the latter requires some changes to the MediaWiki code for table functionalities that are already possible on the Wikipedia Watchlist and which I proposed on phabricator). One could also keep the list-style layout but add e.g. colored tags for different categories of items (like "achievement", "conclusion [about aging-mechanics]", "policy", "meta", etc for types and categories about how significant things are [like items making it into the main tiles of my monthly "Science Summary" being a different category than the shortly summarized items] – having a separate category for less significant findings allows readers to easily skip or filter these out).

---

@Lady3mlnm: and anybody else interested in this topic: What do you think about including these, developing some exclusion criteria and making some layout changes like new sections?

--Prototyperspective (talk) 11:01, 25 June 2021 (UTC)

• @Prototyperspective: I will be very glad if the article develops, but I can't take active participation in this.

Small comment: "2019, 22 August … too much sitting is related to a higher risk of early death" - that is healthy lifestyle, not senescence research directly. I would also not include such things.

--Lady3mlnm (talk) 12:09, 25 June 2021 (UTC)

References