Talk:Toll-like receptor 4

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Tbento2015. Peer reviewers: BioKnitter, Mbarnett2014, Ncameron2013.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 10:38, 17 January 2022 (UTC)

A topic for structure, activation, and signaling pathway

TLR4 is one of the most studied TLR in humans. That would be interesting to have a topic explaining the structure, activation, and signaling pathway. TLR4 is a complex formed by an extracellular leucine-rich repeat domain (LRR) and an intracellular toll/interleukin-1 (IL/1) receptor like. Conformational changes in the TLR4 complex is required to activate signaling cascades. LPS binds a binding protein (LBP), which transfer to CD14 (an adaptor protein) and form a functional LPS protein. LPS-bindings promotes dimerization TLR4/MD-2 which is necessary to activate the signaling pathway (MyD88-dependent and MyD88-independent signaling pathway). I would add a figure showing the TLR4 complex and their ligand proteins.

Tbento2015 (talk) 21:50, 28 January 2017 (UTC)Tbento2015Tbento2015 (talk) 21:50, 28 January 2017 (UTC)

Possible role in effects of obesity

Came across this and thought it might be worth a mention here, but I've got a kid on my lap so I'll just paste a quote or two for now.

"Indeed, high-fat diet feeding triggers the development of obesity, inflammation, insulin resistance, type 2 diabetes and atherosclerosis by mechanisms dependent of the LPS and/or the fatty acids activation of the CD14/TLR4 receptor complex." The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease, Curr Pharm Des. 2009;15(13):1546-58.[1]

"Here we show that nutritional fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the capacity of fatty acids to induce inflammatory signaling in adipose cells or tissue and macrophages is blunted in the absence of TLR4." TLR4 links innate immunity and fatty acid–induced insulin resistance, J Clin Invest. 2006 November 1; 116(11): 3015–3025. [2] --Dan Wylie-Sears 2 (talk) 02:31, 18 March 2010 (UTC)