Talk:Trace amine-associated receptor

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Molecular Biology: MCB

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New review

Latest comment: 7 years ago1 comment1 person in discussion

It's probably worth using this review to add new content to phenethylamine, 3-iodothyronamine, trace amine, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, and this article. Seppi333 (Insert 2¢) 02:28, 4 February 2017 (UTC)Reply

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References

^ Khan MZ, Nawaz W (October 2016). "The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system". Biomed. Pharmacother. 83: 439–449. doi:10.1016/j.biopha.2016.07.002. PMID 27424325.

Human trace amine-associated receptors

Latest comment: 6 years ago4 comments2 people in discussion

@Boghog: do you think the content within and layout of this table is suitable for covering these receptors in the article?

Also, do you think it's reasonable to just list "known/putative functions" and "known ligands" as well as explicitly state "other G protein coupling unknown" for these receptors when so few things are actually known about hTAAR2-hTAAR9? Seppi333 (Insert 2¢) 22:30, 15 May 2018 (UTC)Reply

E.g., this review^[1] lists "CNS and periphery unknown" under the associated putative functions column in table 1 for all of these receptors, except for TAAR1. Off-topic: I emailed Dr. Berry and he was kind enough to multi-license figure 2 from this review so that I could upload it to Commons and use it in TAAR1. Seppi333 (Insert 2¢) 22:36, 15 May 2018 (UTC)Reply

Hi Seppi333. The lack knowledge about what these receptor subtypes do is of course a direct consequence of a lack of selective ligands to probe their function. The way you have presented this in the table I think is fine. The only suggestion I have is to make clear which of the functions are known and which are putative. Also I found the pink color for pseudogenes distracting and unnecessary. It is clear enough from the text that these are pseudogenes. Boghog (talk) 05:03, 16 May 2018 (UTC)Reply

Sounds good. Removing the coloring is fine with me. Thanks for the feedback! Seppi333 (Insert 2¢) 05:20, 16 May 2018 (UTC)Reply

References

^ Berry MD, Gainetdinov RR, Hoener MC, Shahid M (December 2017). "Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges". Pharmacology & Therapeutics. 180: 161–180. doi:10.1016/j.pharmthera.2017.07.002. PMID 28723415.

Add topic

[Human_trace_amines_and_hTAARs_October_2016_review-1] Khan MZ, Nawaz W (October 2016). "The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system". Biomed. Pharmacother. 83: 439–449. doi:10.1016/j.biopha.2016.07.002. PMID 27424325.

[Berry_hTAAR_pharmacology_December_2017_review-2] Berry MD, Gainetdinov RR, Hoener MC, Shahid M (December 2017). "Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges". Pharmacology & Therapeutics. 180: 161–180. doi:10.1016/j.pharmthera.2017.07.002. PMID 28723415.

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