Talk:Trichosporon asteroides/Archive 1

Archive 1

Nancy Yang Peer Review:

General comments:

• I think that overall your outline is very good! Your points are concise and follow a logical order, and are supported by sufficient references. I also think that you have the sub-headings in a good order! Below are just some of my suggestions, and I've linked 3 articles at the bottom that you can check out that are more about the genus in general and specifically about phylogeny (since you seem to have found all the same articles that are specific to the species that I did!).

History and taxonomy

• There is a minor spelling error in the second point with the word species
• You could add that Marçal Mariné et al. (2015) found that it was one of the three most common Trichosporon species isolated from a clinical setting.
• I found an old reference by Takashi Sugita and TakashiNakase (1998) that is a molecular phylogenetic study on Trichosporon and related taxa based on small subunit ribosomal DNA sequences. You can take a look! (linked below)
• You could mention that Ribeiro et al. (2008) found that currently, the genus Trichosporon includes 37 species. Seven of these are implicated in infections in humans: Trichosporon asteroides.
• You could also add that De Baere et al. (2002) found it to be very closely related to the other Trichosporun species T. inkin (via ITS2-PCR fragment length analysis).

Growth and morphology

• You could mention what parts of it's morphology make it difficult to differentiate with Trichosporon asahii, because this could also mean that they are genetically similar.

Physiology

• I'm unsure if the first point about it being able to grow in specific media should be under this subheading or under the "growth and morphology" subheading. I think it could work in both!

Habitat and ecology

• Supporting your point about being found in catheters (from your own reference #9): Ueda et al. (2017) called it a "perigenital cutaneous fungal flora and is sometimes isolated from urethral catheters".
• From one of the sources you listed, it mentions that specifically yeast colonies were isolated from the specimens of blood, urine, aspiration fluid (Kustimur et al. 2002).
• The fourth point about having no virulence in insects could also be appropriate under the "disease" subheading.

Disease

• You can consider a point by your reference #8 Marçal Mariné et al. (2015): superficial infections are more frequently associated with T. asteroides (than the other Trichsporon species) which can also occasionally establish disseminated infections. The same study found that T. asteroides proved to be the least virulent species in their insect virulence model.
• You mention that they rare in zoonotic fungal infection. However you can look at this study done by Ueda et al. (2017) where they were able to isolate Trichosporon asteroides from multifocal, irregularly raised skin lesions on a female bottlenose dolphin (Tursiops truncatus) captured off coast of Japan, which was suspected to have “paracoccidioidomycosis ceti", which is a rare zoonotic fungal infection affecting dolphins and is endemic worldwide. You can take this point lightly thought because this was also the first known case of cutaneous infection caused by T. asteroides in a bottlenose dolphin.
• You can also add that (found in the literature as reviewed by Ueda et al. (2017)), it is known to cause allergies and systemic infections in immunosuppressed patients.
• From Kustimur et al. (2002), they mentioned that T. asteroides is a causative agent of deep-seated fungemia (from your reference #7).

Treatment

• Few papers I have seen mention anything about treating it, however you could mention possible known treatments for human superficial infection and systemic infections in general?

Uses

• I think this was a very unique and suitable subheading to include based on the species!

References The papers I mentioned above are here (aside from the ones already in your reference list):

• https://www.sciencedirect.com/science/article/pii/S1340354098709362 (Molecular phylogenetic study of the basidiomycetous anamorphic yeast genus Trichosporon and related taxa based on small subunit ribosomal DNA sequences).
• https://pdfs.semanticscholar.org/1b33/d01f8d6aa33d5614eda727bf61e80215c736.pdf (Molecular identification and susceptibility testing of Trichosporon isolates from a Brazilian hospital).
• https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-2-21 (Identification of cultured isolates of clinically important yeast species using fluorescent fragment length analysis of the amplified internally transcribed rRNA spacer 2 region).

johnvsjohn86's Peer Review

General comment

• I couldn’t find much information on your fungus but I think the points you’ve stated are precise and straight to the point

History and taxonomy

• What was the reasoning behind the change in specie names?

Growth and morphology

• I think this section is well informed and you did a good job
• I think you should include that fact that Trichosporon asteroids is an urease-positive, non-encapsulated basidiomycetous yeast like fungus (Kurtzman et al. 2013)

Physiology

• Here is a mycobank-like website which includes a lot of information about the physiological properties
  • http://www.westerdijkinstitute.nl/collections/BioloMICS.aspx?Table=Yeasts%20species&Name=Trichosporon%20asteroides&Fields=All&ExactMatch=T

Disease

• Here is an article regarding bloodstream infection of your fungus (Kustimur et al. 2002)
• Here is another article regarding the fungus causing disseminated disease in immunocopromised patients

References

• (Kustimur et al. 2002) https://www.ncbi.nlm.nih.gov/pubmed/12088626 — Preceding unsigned comment added by Johnvsjohn86 (talk • contribs) 01:18, 3 November 2018 (UTC)

Lucas Lisitsky's Peer Review

General Comments

• You seem to have covered all your bases well.
• Though this is just an outline, it would be beneficial to write with more clarity in your final article. For instance:
  • "was first record a responsiblility for systematic infection" is a very clear sentence.
• Given that you have a lot of information with respect to how T. asteroides is distinguished from its close relatives in Trichosporon, it may be worth creating a separate section for it.
• I don't believe you intended to include "Rischin" in the binomial names for some of your synonyms. You may want to correct this.

History and taxonomy

• You have information about its discovery and some of its two of its designations. This is good. It may be worth mentioning
• As you mention in the Growth and morphology section, Guélo 1994, Fissuricella filamenta state is highly similar to T. asteroides, but was judged to be of a distinct taxa due to a combination of morphological and small physiological differences. Some quick research revealed that F. filamenta was proposed as a redesignation of Prototheca filamenta, which you listed as a synonym to T. asteroides.
  • Fissuricella filamenta (P.Arnold & D.G.Ahearn) R.S.Pore, R.F.D'Amato & L.Ajello 1977: 71
  • Arnold, P. & Ahearn, D.G. (1972). The systematics of the genus Prototheca with a description of a new species P. filamenta. Mycologia 64: 265-275.
• Put simply, if F. filamenta is not synonym of T. asteroides, then P. filamenta is also not a synonym. Feel free to correct me if I am mistaken.

Growth and Morphology

• You seem to have covered all your bases here, though it may be of benefit to distinguish between the anamorphic and telomorphic morphology of the species
• It may be worth clarifying some of the more technical language, but this is not essential.

Physiology

• It may be worth mentioning how it was differentiated from its close relatives
  • For instance, Guélo 1994 mentions that T. asteroides can be differentiated from some of its close relatives in Trichosporon by growth with D-galactose, L-rhamnose, erythritol and L-arabinitol but not with glucono-δ-1actone.
  • Whether you include that in this section or the growth section is up to you!
• According to Masao 1926, T. asteroides does not ferment glucose, maltose, sucrose or fructose. This feature is common to all Trichosporon.
  • I can read French, so feel free to ask me if you need help with this article later!

Habitat and ecology

• You should have some citations for your assertion that it is "often" isolated from human superficial infections
  • Guélo 1994 mentions some samples taken from human skin infections, but unless you can find a source that says it is frequently isolated from these, you should rephrase that statement to not make the assertion

Disease

• Clarity will be doubly important for your final article. "Was first record a responsibility for systematic infection", at least in reference to the source paper, might be described as follows:
  • "The first instance of systemic infection by T. asteroides was described in 2002 by Kustimer et al"
• Hopefully I'm not coming off as overly critical. I just want to help you for your final article!

Treatment

• What are some of the challenges in treating Trichosporon infection?
• Fluconazole is used frequently in patients with hematological Trichosporon infection, but what about skin infections?
  • Here is a good review article that describes current treatments of Trichosporon infection — Preceding unsigned comment added by Lucas.lisitsky (talk • contribs) 01:25, 3 November 2018 (UTC)

Uses

• The source states that T. asteroides could be used for this purpose, but it would be nice to find a source stating that this species has been commercially used for this purpose?

Good luck on the final article! I'm happy to help, so don't be afraid to ask!

Lucas.lisitsky (talk) 03:13, 3 November 2018 (UTC)

Some suggestions

• references look OK
• “specie” is not a word, both the singular and plural are, “species”
• reference tags should follow text or punctuation with no space
• this is a common medical fungus, and there should be a fair amount of material you could include in your physiology section
• I made a few edits in your text that hopefully will be helpful as you develop your full article
• try to use common terminology if possible, e.g., cerebriform, farinose
• your piece on the dolphin disease is interesting and will benefit from a clearer explanation

Medmyco (talk) 19:52, 17 November 2018 (UTC)