Talk:Vesicle-associated membrane protein

Untitled

I don't know who created this page, but the pdb model of the synaptobrevin is misleading(!) in sense that what you see is NOT the synaptobrevin that should be a long alpha-helical protein with no beta-strand domains, what is given as monomer is some adaptor protein that binds to synaptobrevin, not synaptobrevin itself. Danko Georgiev MD 02:49, 9 February 2006 (UTC)

You are absolutely correct. I don't how I could have made such an obvious mistake when I made the image. I'll take the image off and add a correct one when I get a chance. Salsb 14:31, 9 February 2006 (UTC)

O.K. I have added correct image of the core SNARE complex. What one can see is the portion of the VAMP-2 that interacts with syntaxin and SNAP-25. Personally I am interested how one can collect in some 3D environment fragments of different pdb files and create a 3D image of cell interior. If someone knows how this can be in principle done, let he/she post his comment, here. Danko Georgiev MD 05:48, 10 February 2006 (UTC)

I have created new more general entry on VAMP, since not all VAMPs are synaptobrevins. The synaptobrevin has its own article. Danko Georgiev MD 11:50, 19 May 2006 (UTC)

It would be useful to add another introductory sentence (before the breakdown list of the individual VAMPs) explaining that vesicle-associated membrane proteins contribute one of the four alpha helices that make up the coiled-coil quaternary structure of the SNARE complex. Chinny11 (talk) 04:32, 1 October 2016 (UTC)

References