Talk:Vilazodone

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SSRI?

Latest comment: 4 years ago3 comments2 people in discussion

http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4c55ccfb-c4cf-11df-851a-0800200c9a66#section-11

"VIIBRYD Tablets for oral administration contain polymorph Form IV vilazodone hydrochloride (HCl), a selective serotonin reuptake inhibitor and a 5HT1A receptor partial agonist."

Is it really an SSRI? If yes, please add to article.--4h8s (talk) 14:58, 3 October 2013 (UTC)Reply

It’s another class technically. Think of it as ssri 2.0. Most the new drugs hit SERT then also try and hit 5-HT1A and maybe a few others to get a favorable effect profile. Technically a SERM serotonin receptor modulator. Eg it has multiple effects in the serotonin system - and likely other monoamine systems. Dopamine norepinephrine epinephrine (adrenergic alpha, beta) etc Gizmo.AT (talk) 04:08, 31 August 2020 (UTC)Reply

To clarify - anything that has a low number next to “SERT” in the pharmacokinetics section is technically an SSRI in the “lay” parlance. E.g it has a significant effect at the reuptake transporter Gizmo.AT (talk) 04:11, 31 August 2020 (UTC)Reply

Clinically insignificant effects at the NET receptor

Latest comment: 4 years ago1 comment1 person in discussion

Yea freaking right. Skim the side effects and effects, and the NET activity (or downstream effects) are rather important here. Speaking from experience here. Was a bit surprised at how activating and sympathomimetic this was. Not in a good way. D/c’d after a month or two of sweaty diarrhea. Gizmo.AT (talk) 04:04, 31 August 2020 (UTC)Reply

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