In molecular biology, TauD refers to a protein domain that in many enteric bacteria is used to break down taurine (2-aminoethanesulfonic acid) as a source of sulfur under stress conditions. In essence, they are domains found in enzymes that provide bacteria with an important nutrient.

TauD
ensemble refinement of the protein crystal structure of gene product from arabidopsis thaliana at3g21360
Identifiers
SymbolTauD
PfamPF02668
Pfam clanCL0029
InterProIPR003819
SCOP21gy9 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Function

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This protein family consists of TauD/TfdA taurine catabolism dioxygenases. The Escherichia coli tauD gene is required for the utilization of taurine (2-aminoethanesulfonic acid) as a sulfur source and is expressed only under conditions of sulfate starvation. TauD is an alpha-ketoglutarate-dependent dioxygenase catalyzing the oxygenolytic release of sulfite from taurine.[1] The 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase from Burkholderia sp. (strain RASC) also belongs to this family.[2] TfdA from Ralstonia eutropha (Alcaligenes eutrophus) is a 2,4-D monooxygenase.[3]

Structure

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This structure has a number of alpha helices and beta sheets.

References

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  1. ^ Eichhorn E, van der Ploeg JR, Kertesz MA, Leisinger T (September 1997). "Characterization of alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coli". J. Biol. Chem. 272 (37): 23031–6. doi:10.1074/jbc.272.37.23031. PMID 9287300.
  2. ^ Suwa Y, Wright AD, Fukimori F, Nummy KA, Hausinger RP, Holben WE, Forney LJ (July 1996). "Characterization of a chromosomally encoded 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase from Burkholderia sp. strain RASC". Appl. Environ. Microbiol. 62 (7): 2464–9. Bibcode:1996ApEnM..62.2464S. doi:10.1128/AEM.62.7.2464-2469.1996. PMC 168028. PMID 8779585.
  3. ^ Streber WR, Timmis KN, Zenk MH (July 1987). "Analysis, cloning, and high-level expression of 2,4-dichlorophenoxyacetate monooxygenase gene tfdA of Alcaligenes eutrophus JMP134". J. Bacteriol. 169 (7): 2950–5. doi:10.1128/jb.169.7.2950-2955.1987. PMC 212332. PMID 3036764.
This article incorporates text from the public domain Pfam and InterPro: IPR003819