Taxoid 14beta-hydroxylase (EC 1.14.13.146) is an enzyme with systematic name 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl-acetate,NADPH:oxygen 14-oxidoreductase.[1] This enzyme catalyses the following chemical reaction
| Taxoid 14beta-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.146 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O
Taxoid 14beta-hydroxylase requires cytochrome P450.
References
edit- ^ Jennewein S, Rithner CD, Williams RM, Croteau R (May 2003). "Taxoid metabolism: Taxoid 14beta-hydroxylase is a cytochrome P450-dependent monooxygenase". Archives of Biochemistry and Biophysics. 413 (2): 262–70. doi:10.1016/s0003-9861(03)00090-0. PMID 12729625.
External links
edit- Taxoid+14beta-hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
