Taxoid 7beta-hydroxylase (EC 1.14.13.147) is an enzyme with systematic name taxusin,NADPH:oxygen 7-oxidoreductase.[1] This enzyme catalyses the following chemical reaction
| Taxoid 7beta-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.147 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- taxusin + O2 + NADPH + H+ 7beta-hydroxytaxusin + NADP+ + H2O
Taxoid 7beta-hydroxylase requires cytochrome P450.
References
edit- ^ Chau M, Jennewein S, Walker K, Croteau R (May 2004). "Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7 beta-hydroxylase". Chemistry & Biology. 11 (5): 663–72. doi:10.1016/j.chembiol.2004.02.025. PMID 15157877.
External links
edit- Taxoid+7beta-hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
