Teg49 is a non-coding RNA present in the extended promoter region of the staphylococcal accessory regulator sarA. It was identified by RNA-seq and confirmed by Northern blot. It is modulated by sigB (sarA regulator[1]) and cshA (an ATP-dependant DEAD box RNA helicase[2]) and it most likely contributes to virulence of S. aureus by modulating SarA expression.[3]
| Teg49 sRNA | |
|---|---|
 Predicted secondary structure and sequence conservation of Teg49 small RNA | |
| Identifiers | |
| Rfam | RF02696 |
| Other data | |
| Domain(s) | Bacteria |
| GO | GO:0009405 |
| SO | SO:0000370 |
| PDB structures | PDBe |
References
edit- ^ Cheung AL, Chien YT, Bayer AS (March 1999). "Hyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus". Infection and Immunity. 67 (3): 1331–1337. doi:10.1128/IAI.67.3.1331-1337.1999. PMC 96465. PMID 10024579.
- ^ Oun S, Redder P, Didier JP, François P, Corvaglia AR, Buttazzoni E, Giraud C, Girard M, Schrenzel J, Linder P (January 2013). "The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus". RNA Biology. 10 (1): 157–165. doi:10.4161/rna.22899. PMC 3590232. PMID 23229022.
- ^ Kim S, Reyes D, Beaume M, Francois P, Cheung A (October 2014). "Contribution of teg49 small RNA in the 5′ upstream transcriptional region of sarA to virulence in Staphylococcus aureus". Infection and Immunity. 82 (10): 4369–4379. doi:10.1128/IAI.02002-14. PMC 4187880. PMID 25092913.
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