| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Detroit City FC (C) | 18 | 14 | 3 | 1 | 35 | 10 | +25 | 45[a] |
| 2 | California United Strikers FC | 18 | 9 | 6 | 3 | 31 | 20 | +11 | 33 |
| 3 | Los Angeles Force | 18 | 7 | 9 | 2 | 20 | 14 | +6 | 30[a] |
| 4 | New Amsterdam FC | 18 | 7 | 2 | 9 | 29 | 29 | 0 | 23 |
| 5 | Chattanooga FC | 18 | 7 | 2 | 9 | 20 | 21 | −1 | 23 |
| 6 | Chicago House AC | 18 | 7 | 2 | 9 | 18 | 26 | −8 | 23 |
| 7 | Michigan Stars FC | 18 | 5 | 6 | 7 | 24 | 24 | 0 | 21 |
| 8 | Stumptown AC | 18 | 4 | 8 | 6 | 13 | 18 | −5 | 20 |
| 9 | Maryland Bobcats FC | 18 | 5 | 5 | 8 | 20 | 28 | −8 | 20 |
| 10 | San Diego 1904 FC | 18 | 2 | 3 | 13 | 17 | 37 | −20 | 9 |
Source: nisasoccer.com
Rules for classification: 1) points; 2) goal differential; 3) goals scored; 4) head-to-head
(C) Champions
Notes:
Rules for classification: 1) points; 2) goal differential; 3) goals scored; 4) head-to-head
(C) Champions
Notes:
- ^ "NISA League Statement on LA Force-DCFC Match Cancelation". NISAofficial.com. National Independent Soccer Association. November 10, 2021. Retrieved November 10, 2021.