- Group A
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification | WHU | FRE | OLY | TSC | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  West Ham United
|
6 | 5 | 0 | 1 | 10 | 4 | +6 | 15 | Advance to round of 16 | — | 2–0 | 1–0 | 3–1 | |
| 2 |  SC Freiburg
|
6 | 4 | 0 | 2 | 17 | 7 | +10 | 12 | Advance to knockout round play-offs | 1–2 | — | 5–0 | 5–0 | |
| 3 |  Olympiacos
|
6 | 2 | 1 | 3 | 11 | 14 | −3 | 7 | Transfer to Europa Conference League | 2–1 | 2–3 | — | 5–2 | |
| 4 |  TSC
|
6 | 0 | 1 | 5 | 6 | 19 | −13 | 1 | 0–1 | 1–3 | 2–2 | — |
- Group B
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification | BHA | MAR | AJA | AEK | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Brighton & Hove Albion
|
6 | 4 | 1 | 1 | 10 | 5 | +5 | 13 | Advance to round of 16 | — | 1–0 | 2–0 | 2–3 | |
| 2 |  Marseille
|
6 | 3 | 2 | 1 | 14 | 10 | +4 | 11 | Advance to knockout round play-offs | 2–2 | — | 4–3 | 3–1 | |
| 3 |  Ajax
|
6 | 1 | 2 | 3 | 10 | 13 | −3 | 5 | Transfer to Europa Conference League | 0–2 | 3–3 | — | 3–1 | |
| 4 | AEK Athens
|
6 | 1 | 1 | 4 | 6 | 12 | −6 | 4 | 0–1 | 0–2 | 1–1 | — |
- Group C
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification | RAN | SPP | BET | ALI | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  Rangers
|
6 | 3 | 2 | 1 | 8 | 6 | +2 | 11 | Advance to round of 16 | — | 2–1 | 1–0 | 1–1 | |
| 2 |  Sparta Prague
|
6 | 3 | 1 | 2 | 9 | 7 | +2 | 10 | Advance to knockout round play-offs | 0–0 | — | 1–0 | 3–2 | |
| 3 |  Real Betis
|
6 | 3 | 0 | 3 | 9 | 7 | +2 | 9 | Transfer to Europa Conference League | 2–3 | 2–1 | — | 4–1 | |
| 4 |  Aris Limassol
|
6 | 1 | 1 | 4 | 7 | 13 | −6 | 4 | 2–1 | 1–3 | 0–1 | — |
- Group D
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification | ATA | SCP | STU | RAK | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  Atalanta
|
6 | 4 | 2 | 0 | 12 | 4 | +8 | 14 | Advance to round of 16 | — | 1–1 | 1–0 | 2–0 | |
| 2 |  Sporting CP
|
6 | 3 | 2 | 1 | 10 | 6 | +4 | 11 | Advance to knockout round play-offs | 1–2 | — | 3–0 | 2–1 | |
| 3 |  Sturm Graz
|
6 | 1 | 1 | 4 | 4 | 9 | −5 | 4[a] | Transfer to Europa Conference League | 2–2 | 1–2 | — | 0–1 | |
| 4 |  Raków Częstochowa
|
6 | 1 | 1 | 4 | 3 | 10 | −7 | 4[a] | 0–4 | 1–1 | 0–1 | — |
- Group E
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification | LIV | TOU | USG | LAS | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Liverpool
|
6 | 4 | 0 | 2 | 17 | 7 | +10 | 12 | Advance to round of 16 | — | 5–1 | 2–0 | 4–0 | |
| 2 | Toulouse
|
6 | 3 | 2 | 1 | 8 | 9 | −1 | 11 | Advance to knockout round play-offs | 3–2 | — | 0–0 | 1–0 | |
| 3 |  Union Saint-Gilloise
|
6 | 2 | 2 | 2 | 5 | 8 | −3 | 8 | Transfer to Europa Conference League | 2–1 | 1–1 | — | 2–1 | |
| 4 | LASK
|
6 | 1 | 0 | 5 | 6 | 12 | −6 | 3 | 1–3 | 1–2 | 3–0 | — |
- Group F
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification | VIL | REN | MHA | PAO | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Villarreal
|
6 | 4 | 1 | 1 | 9 | 7 | +2 | 13 | Advance to round of 16 | — | 1–0 | 0–0 | 3–2 | |
| 2 | Rennes
|
6 | 4 | 0 | 2 | 13 | 6 | +7 | 12 | Advance to knockout round play-offs | 2–3 | — | 3–0 | 3–1 | |
| 3 |  Maccabi Haifa
|
6 | 1 | 2 | 3 | 3 | 9 | −6 | 5 | Transfer to Europa Conference League | 1–2 | 0–3 | — | 0–0 | |
| 4 | Panathinaikos
|
6 | 1 | 1 | 4 | 7 | 10 | −3 | 4 | 2–0 | 1–2 | 1–2 | — |
- Group G
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification | SLP | ROM | SRV | SHE | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Slavia Prague
|
6 | 5 | 0 | 1 | 17 | 4 | +13 | 15 | Advance to round of 16 | — | 2–0 | 4–0 | 6–0 | |
| 2 | Roma
|
6 | 4 | 1 | 1 | 12 | 4 | +8 | 13 | Advance to knockout round play-offs | 2–0 | — | 4–0 | 3–0 | |
| 3 |  Servette
|
6 | 1 | 2 | 3 | 4 | 13 | −9 | 5 | Transfer to Europa Conference League | 0–2 | 1–1 | — | 2–1 | |
| 4 |  Sheriff Tiraspol
|
6 | 0 | 1 | 5 | 5 | 17 | −12 | 1 | 2–3 | 1–2 | 1–1 | — |
- Group H
| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification | LEV | QAR | MOL | HAC | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Bayer Leverkusen
|
6 | 6 | 0 | 0 | 19 | 3 | +16 | 18 | Advance to round of 16 | — | 5–1 | 5–1 | 4–0 | |
| 2 |  Qarabağ
|
6 | 3 | 1 | 2 | 7 | 9 | −2 | 10 | Advance to knockout round play-offs | 0–1 | — | 1–0 | 2–1 | |
| 3 |  Molde
|
6 | 2 | 1 | 3 | 12 | 12 | 0 | 7 | Transfer to Europa Conference League | 1–2 | 2–2 | — | 5–1 | |
| 4 |  BK Häcken
|
6 | 0 | 0 | 6 | 3 | 17 | −14 | 0 | 0–2 | 0–1 | 1–3 | — |