Template:Did you know nominations/17q12 microdeletion syndrome

The following is an archived discussion of the DYK nomination of the article below. Please do not modify this page. Subsequent comments should be made on the appropriate discussion page (such as this nomination's talk page, the article's talk page or Wikipedia talk:Did you know), unless there is consensus to re-open the discussion at this page. No further edits should be made to this page.

The result was: promoted by Edge3 (talk) 01:53, 14 February 2021 (UTC)

17q12 microdeletion syndrome

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... that 17q12 microdeletion syndrome, an underdiagnosed genetic disorder, is thought to be a major genetic risk factor for autism and schizophrenia? Source: 17q12 Recurrent Deletion Syndrome, Deletion 17q12 Is a Recurrent Copy Number Variant that Confers High Risk of Autism and Schizophrenia

Reviewed: Did you know nominations/John C. England

Created by Vaticidalprophet (talk). Self-nominated at 07:41, 4 February 2021 (UTC).

Long enough, sources are primarily academic, and the hook is factual and sufficient. ViperSnake151 Talk 16:48, 4 February 2021 (UTC)

Hi Vaticidalprophet, given this is a medical article, this hook concerns me. The syndrome in question is not the sole cause of autism and schizophrenia, nor does it always cause these conditions. The word "major" makes me especially wary, and doesn't seem to be used in that sense in the source cited for the sentence in the article including "major". CMD (talk) 13:55, 12 February 2021 (UTC)

Thanks for coming in. The claim made is 'a major', which is important and massively different to 'the major', let alone 'sole'; the compared prevalence estimates alone make it very clear this is a major genetic cause. Keep in mind most of the major genetic causes for these conditions make up very small percentages of the total people with them, and the ones here are totally in line with a major cause with this sort of prevalence. (For a comparison with a somewhat more common disorder, DiGeorge syndrome is about 1/4000 of the general population and ~2% of people with schizophrenia; running a DYK about it being a major genetic cause of schizophrenia would be completely fine and uncontroversial, because it 100% is and is so famously so to ironically be hard to cite/"everyone knows this".) Here's a more direct cite (the cite originally given is for a literature review on every aspect of the disorder, while this is directly on those conditions). Vaticidalprophet (talk) 14:09, 12 February 2021 (UTC)

And for what it's worth, I've discussed this article with WikiProject Medicine regulars for unrelated reasons, so it's had a fair few medical eyes on it and no one has raised concerns with that sort of wording. Vaticidalprophet (talk) 14:11, 12 February 2021 (UTC)

Discussions with WP:MED are certainly helpful. That CellPress paper calls it a "major risk factor for", which is a more usual sort of wording than "major [genetic] cause of", and more reserved. Would you mind changing it to "...major genetic risk factor for autism..."? CMD (talk) 14:35, 12 February 2021 (UTC)

Bit less punchy, but still a decent hook. Done. Vaticidalprophet (talk) 14:41, 12 February 2021 (UTC)

Sorry about the punchiness, it's a substantial difference. Restoring the tick, but can I ask you to tweak the article a little (eg. DiGeorge syndrome uses "risk", "high-risk group") and add that paper as a second hook source? CMD (talk) 14:52, 12 February 2021 (UTC)

Second source done. Vaticidalprophet (talk) 15:05, 12 February 2021 (UTC)