Template:Did you know nominations/Ixazomib

The following is an archived discussion of the DYK nomination of the article below. Please do not modify this page. Subsequent comments should be made on the appropriate discussion page (such as this nomination's talk page, the article's talk page or Wikipedia talk:Did you know), unless there is consensus to re-open the discussion at this page. No further edits should be made to this page.

The result was: promoted by Cwmhiraeth (talk) 06:10, 3 February 2017 (UTC)

Ixazomib

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... that the anti-cancer drug ixazomib is metabolized by at least eight different enzymes? Ninlaro EPAR, p. 16. The number eight comes from the 7 mentioned CYPs plus at least one non-CYP enzyme per the source. (Actually could make that 9, as the source mentions non-CYPs in the plural.)

Reviewed: Pyrithione
Comment: If too technical, "metabolized" could be replaced with "broken down" or "degraded".

5x expanded by Anypodetos (talk). Self-nominated at 20:23, 5 January 2017 (UTC).

New enough at the time of nomination (5x expanded on 4-6 Jan), long enough, no copyvio or content problems. The hook fact is cited and verified, with the small quibble that the hook text could be taken to mean in vivo data but the experiments were in vitro, and the ones that yielded the percentages given in the article text were performed at concentrations above what would be clinically expected. Also, the last sentence "...Phase I/II trials for various other conditions." ends without a reference (though it's certainly true). I don't think "metabolized" is too technical, but I would link enzymes as well. Opabinia regalis (talk) 23:18, 13 January 2017 (UTC)

Thanks for the review! The only way I see to make the hook really unambiguous is adding "…in vitro?". No sure this is really necessary; at any rate, I've made the relevant sentence in the article a bit more precise. Other issues addressed. --ἀνυπόδητος (talk) 08:34, 14 January 2017 (UTC)

Looks good, thanks! How about "...can be metabolized"? Opabinia regalis (talk) 04:09, 15 January 2017 (UTC)

Yes, that's good: --ἀνυπόδητος (talk) 08:29, 15 January 2017 (UTC)

ALT1 ... that the anti-cancer drug ixazomib can be metabolized by at least eight different enzymes?
- Ah crap, sorry I took so long to get back to this, Anypodetos, and thanks to Northamerica1000 for the reminder! :) Looks good! Opabinia regalis (talk) 20:26, 30 January 2017 (UTC)