Template:Did you know nominations/beta-Hydroxy beta-methylbutyric acid

The following is an archived discussion of the DYK nomination of the article below. Please do not modify this page. Subsequent comments should be made on the appropriate discussion page (such as this nomination's talk page, the article's talk page or Wikipedia talk:Did you know), unless there is consensus to re-open the discussion at this page. No further edits should be made to this page.

The result was: promoted by Yoninah (talk) 00:38, 21 January 2018 (UTC)

Beta-Hydroxy beta-methylbutyric acid

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Structural formula of the free acid form of HMB

... that HMB (pictured) has been shown to prevent age-related muscle loss, increase exercise-induced gains in muscle size, muscle strength, and lean body mass, reduce muscle damage, and speed recovery from exercise?
Source: In the body of this article, the 5 effects listed after "age-related muscle loss" in this hook are cited by the 6 medical/systematic reviews or meta-analyses included in Special:permalink/817078326#cite_note-45; the effect on age-related muscle loss (i.e., sarcopenia) is cited by references [10] and [11] in the preceding note link (i.e., PMID 26169182 and PMID 28493406) as well as Special:Permalink/817078326#cite_note-HMB_for_sarcopenia_and_sarcopenic_obesity_–_October_2017_review-13 (PMID 29086232). All of the citations to those references in this article include a relevant quote in the citation's quote parameter; most of those quotes cover the effects listed here.
- ALT1: ... that the dietary supplement HMB (pictured) has been shown to increase muscle mass and improve muscle strength in older adults with sarcopenia?
  Source: See the references listed above for "age-related muscle loss"; for brevity, I'll just quote 1 review:
  • Clinical trials performed in older adults confirm that HMB can attenuate the progression of sarcopenia in elderly subjects. HMB supplementation results in an increase in skeletal muscle mass and strength in the elderly and its effect is even greater when combined with physical exercise. – PMID 29086232
- ALT2: ... that, in healthy adults, HMB (pictured) has been shown to increase exercise-induced gains in muscle size, muscle strength, and lean body mass, reduce muscle damage, and speed recovery from exercise?
  Source: See above; I'll just quote 2 reviews here:
  • The reports summarized here indicate that HMB provides a number of benefits to subjects involved in strength-power and endurance sports. The effects on muscle mass and strength, particularly during resistance training, are likely related to the suppression of proteolysis and a positive effect on protein synthesis. Its benefits in aerobic performance are probably more associated with improved mitochondrial biogenesis and fat oxidation. Favourable effects on the recovery from exercise-induced damage may be related to the role of HMB as a precursor of cholesterol, which modulates membrane fluidity and affects ion channels, and membrane excitability. ... Studies have demonstrated that HMB can prevent the development of sarcopenia in elderly subjects and that the optimal action of HMB on muscle growth and strength occurs when it is combined with exercise. – PMID 28493406
  • The [International Society of Sports Nutrition] has concluded the following. 1. HMB can be used to enhance recovery by attenuating exercise induced skeletal muscle damage in trained and untrained populations. ... 4. Thirty-eight mg·kg·BM-1 daily of HMB has been demonstrated to enhance skeletal muscle hypertrophy, strength, and power in untrained and trained populations when the appropriate exercise prescription is utilized. – PMID 23374455

Comment: While the acronym "HMB" might seem more ambiguous relative to using the article title, some of the reviews of clinical studies with this compound focus exclusively on either the conjugate acid (β-hydroxy β-methylbutyric acid) or the conjugate base (β-hydroxy β-methylbutyrate). "HMB" refers to both, every review uses the acronym "HMB", and both forms are commercially available.

Improved to Good Article status by Seppi333 (talk) and Boghog (talk). Nominated by Seppi333 (talk) at 00:39, 27 December 2017 (UTC).

Comment: In my opinion the chemical structure is not picture-worthy. David notMD (talk) 04:46, 27 December 2017 (UTC)

GA, in time, long enough, sourced, inline hook citations check out (Seppi333, thanks for the note under ALT0), no apparent copyvios, QPQ not needed (2nd DYK). Image is fine, although I agree with David notMD. Ho-o-oh coulda almost worked for Christmas, though... --Usernameunique (talk) 16:50, 27 December 2017 (UTC)