| Progestogen | Class | Dosea | Bioavailability | Half-life | Refs |
|---|---|---|---|---|---|
| Allylestrenol | Estrane | NA | ? | Prodrug | |
| Chlormadinone acetate | Pregnane | 2 mg | ~100% | 80 hours | |
| Cyproterone acetate | Pregnane | 2 mg | ~100% | 54–79 hours | |
| Desogestrel | Gonane | 0.15 mg | 63% | Prodrug | |
| Dienogest | Gonane | 4 mg | 96% | 11–12 hours | |
| Drospirenone | Spirolactone | 3 mg | 66% | 31–33 hours | |
| Dydrogesterone | Pregnane | 10 mg | 28% | 14–17 hours | |
| Etynodiol diacetate | Estrane | NA | ? | Prodrug | |
| Gestodene | Gonane | 0.075 mg | 88–99% | 12–14 hours | |
| Hydroxyprogesterone caproate | Pregnane | ND | – | 8 daysb | [1] |
| Levonorgestrel | Gonane | 0.15–0.25 mg | 90% | 10–13 hours | |
| Lynestrenol | Estrane | NA | ? | Prodrug | |
| Medrogestone | Pregnane | 5 mg | ~100% | 35 hours | |
| Medroxyprogesterone acetate | Pregnane | 10 mg | ~100% | 24 hours | |
| Megestrol acetate | Pregnane | 160 mg | ~100% | 22 hours | |
| Nomegestrol acetate | Pregnane | 2.5 mg | 60% | 50 hours | [2][3] |
| Norethisterone | Estrane | 1 mg | 64% | 8 hours | |
| Norethisterone acetate | Estrane | NA | ? | Prodrug | |
| Noretynodrel | Estrane | NA | ? | Prodrug | |
| Norgestimate | Gonane | NA | ? | Prodrug | |
| Progesterone (micronized) | Pregnane | 100–200 mg | <2.4% | 5 hours | [4][5] |
| Promegestone | Pregnane | NA | ? | Prodrug | |
| Tibolone | Estrane | NA | ? | Prodrug | |
| Trimegestone | Pregnane | 0.5 mg | ~100% | 15 hours | |
| Notes: All by oral administration, unless otherwise noted. Footnotes: a = For the listed pharmacokinetic values. b = By intramuscular injection. Sources: [6][7][8][9][10] | |||||
References
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- ^ Lello, Stefano (2010). "Nomegestrol Acetate". Drugs. 70 (5): 541–559. doi:10.2165/11532130-000000000-00000. ISSN 0012-6667. PMID 20329803.
- ^ Ruan, Xiangyan; Seeger, Harald; Mueck, Alfred O. (2012). "The pharmacology of nomegestrol acetate". Maturitas. 71 (4): 345–353. doi:10.1016/j.maturitas.2012.01.007. ISSN 0378-5122.
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- ^ Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, Thijssen JH (December 2003). "Classification and pharmacology of progestins". Maturitas. 46 Suppl 1: S7–S16. doi:10.1016/j.maturitas.2003.09.014. PMID 14670641.
- ^ Kuhl H (2011). "Pharmacology of Progestogens" (PDF). J Reproduktionsmed Endokrinol. 8 (1): 157–177.
- ^ Marc A. Fritz; Leon Speroff (28 March 2012). Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. pp. 761–. ISBN 978-1-4511-4847-3.
- ^ Lauritzen C (September 1990). "Clinical use of oestrogens and progestogens". Maturitas. 12 (3): 199–214. doi:10.1016/0378-5122(90)90004-P. PMID 2215269.
- ^ Kuhl H (September 1990). "Pharmacokinetics of oestrogens and progestogens". Maturitas. 12 (3): 171–97. doi:10.1016/0378-5122(90)90003-o. PMID 2170822.