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Template:Protein binding and metabolic clearance rates of estrogens

Protein binding and metabolic clearance rates of estrogens
Compound RBATooltip Relative binding affinity to
SHBGTooltip sex hormone-binding globulin (%)		 Bound to
SHBG (%)		 Bound to
albumin (%)		 Total
bound (%)		 MCRTooltip Metabolic clearance rate
(L/day/m2)
17β-Estradiol 50 37 61 98 580
Estrone 12 16 80 96 1050
Estriol 0.3 1 91 92 1110
Estrone sulfate 0 0 99 99 80
17β-Dihydroequilin 30 ? ? ? 1250
Equilin 8 26 13 ? 2640
17β-Dihydroequilin sulfate 0 ? ? ? 375
Equilin sulfate 0 ? ? ? 175
Δ8-Estrone ? ? ? ? 1710
Notes: RBA for SHBG (%) is compared to 100% for testosterone. Sources: [1]

References

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  1. ^ Kuhl H (2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration" (PDF). Climacteric. 8 Suppl 1: 3–63. doi:10.1080/13697130500148875. PMID 16112947.
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