Template talk:Leucine metabolism in humans

Annotating the mevalonate pathway and usage in 3 articles

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@Boghog: This diagram currently suggests that mevalonate is metabolized directly into cholesterol, which it isn't; do you think it would help to clarify this if I added a "mevalonate pathway" annotation next to the line connecting mevalonate to cholesterol? If I were to add that annotation, I could use either an unpiped link to the article on the mevalonate pathway or a piped link to File:Mevalonate pathway.svg, which I think would be a better link target than the article for this purpose.

Also, β-hydroxybutyrate, acetoacetate, and β-hydroxybutyrate dehydrogenase all lack a metabolic pathway diagram at the moment. I realize that HMG-CoA (KEGG link) and acetoacetate (KEGG link) are generated through several metabolic pathways – not just from leucine – so I could indicate this in the caption if this diagram is transcluded to those articles. Alternatively, I could crop out everything above HMG-CoA or HMB-CoA in this diagram and add that to those articles instead. Besides this template, the only other high-quality image I've seen which illustrates those 3 articles I mentioned in a metabolic pathway is File:Ketogenesis.svg. Which of these diagrams do you think is better suited for those articles? Seppi333 (Insert ) 07:36, 31 January 2018 (UTC)Reply

Nevermind, I went ahead and added the mevalonate pathway image file annotation and annotated the thiolase enzyme for acetyl-CoA↔acetoacetyl-CoA. Seppi333 (Insert ) 15:17, 1 February 2018 (UTC)Reply

Section reflist

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  1. ^ a b Wilson JM, Fitschen PJ, Campbell B, Wilson GJ, Zanchi N, Taylor L, Wilborn C, Kalman DS, Stout JR, Hoffman JR, Ziegenfuss TN, Lopez HL, Kreider RB, Smith-Ryan AE, Antonio J (February 2013). "International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB)". Journal of the International Society of Sports Nutrition. 10 (1): 6. doi:10.1186/1550-2783-10-6. PMC 3568064. PMID 23374455.
  2. ^ a b Kohlmeier M (May 2015). "Leucine". Nutrient Metabolism: Structures, Functions, and Genes (2nd ed.). Academic Press. pp. 385–388. ISBN 978-0-12-387784-0. Retrieved 6 June 2016. Energy fuel: Eventually, most Leu is broken down, providing about 6.0kcal/g. About 60% of ingested Leu is oxidized within a few hours ... Ketogenesis: A significant proportion (40% of an ingested dose) is converted into acetyl-CoA and thereby contributes to the synthesis of ketones, steroids, fatty acids, and other compounds
    Figure 8.57: Metabolism of L-leucine