Tetrahymanol synthase (EC 4.2.1.123, squalene tetrahymanol cyclase) is an enzyme with systematic name squalene hydro-lyase (tetrahymanol forming).[1][2] This enzyme catalyses the following chemical reaction
| Tetrahymanol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.123 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- tetrahymanol squalene + H2O
The reaction occurs in the reverse direction.
This enzyme is isolated from Tetrahymena protozoans.
References
edit- ^ Saar J, Kader JC, Poralla K, Ourisson G (September 1991). "Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila". Biochimica et Biophysica Acta (BBA) - General Subjects. 1075 (1): 93–101. doi:10.1016/0304-4165(91)90080-z. PMID 1892870.
- ^ Giner JL, Rocchetti S, Neunlist S, Rohmer M, Arigoni D (June 2005). "Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis". Chemical Communications (24): 3089–91. doi:10.1039/b504300j. PMID 15959594.
External links
edit- Tetrahymanol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
