The End of Everything may refer to:
- The End of Everything (album), an album by Moby under the pseudonym Voodoo Child
- The End of Everything (EP), an extended play by Noah Cyrus
- The End of Everything (novel), a novel by Megan Abbott
- "The End of Everything" (Fear the Walking Dead), an episode of Fear the Walking Dead
- "End of Everything", a song by Melanie C from the album Melanie C
- The End of the End of Everything: Stories, a 2015 story collection by Dale Bailey
- The End of Everything (Astrophysically Speaking), a 2020 book by Katie Mack