The Genomic HyperBrowser is a web-based system for statistical analysis of genomic annotation data.[1][2]
History
editThe Genomic HyperBrowser has been developed since early 2008 and went public in December 2010. The latest version of the system (v1.6) was released in May 2013.[3][4] The system is developed by the Norwegian Bioinformatics Platform, a joint project between the University of Bergen, the University of Oslo, the Norwegian University of Science and Technology, the University of Tromsø and the Norwegian University of Life Sciences.[1][5] The Genomic HyperBrowser is free software under the GNU GPL v3.
Use
editThe HyperBrowser allows a range of genomic investigations (for example, including regulation of gene expression, disease association or epigenetic modifications of the genome).[4] The primary focus of the system is on statistical inference on relations between genomic tracks, though simpler descriptive statistics and analysis of individual tracks is also supported. An example of analysis is to investigate the relationship between histone modifications and gene expression, using ChIP-based tracks of histone modifications versus tracks of genes marked with expression values from a microarray experiment. The web server includes a sizable collection of annotation tracks, and also supports user-uploaded tracks. The Genomic HyperBrowser runs as a stand-alone system, but is tightly integrated with the Galaxy scientific workflow platform for handling of genomic data, especially at the user interface side.
A project to compile a differential disease regulome used the Genomic HyperBrowser in mapping transcription factors against all human diseases.[6]
See also
editReferences
edit- ^ a b "The Genomic HyperBrowser". Retrieved 7 August 2015.
- ^ Sandve GK, Gundersen S, Rydbeck H, et al. (2010). "The Genomic HyperBrowser: inferential genomics at the sequence level". Genome Biol. 11 (12): R121. doi:10.1186/gb-2010-11-12-r121. PMC 3046481. PMID 21182759.
- ^ "Announcements - the Genomic HyperBrowser - Help". Retrieved 7 August 2015.
- ^ a b Sandve, G. K.; Gundersen, S.; Johansen, M.; Glad, I. K.; Gunathasan, K.; Holden, L.; Holden, M.; Liestol, K.; Nygard, S.; Nygaard, V.; Paulsen, J.; Rydbeck, H.; Trengereid, K.; Clancy, T.; Drablos, F.; Ferkingstad, E.; Kalas, M.; Lien, T.; Rye, M. B.; Frigessi, A.; Hovig, E. (30 April 2013). "The Genomic HyperBrowser: an analysis web server for genome-scale data". Nucleic Acids Research. 41 (W1): W133–W141. doi:10.1093/nar/gkt342. PMC 3692097. PMID 23632163.
- ^ "About - Site". Retrieved 7 August 2015.
- ^ Sandve, Geir K; Gundersen, Sveinung; Rydbeck, Halfdan; Glad, Ingrid K; Holden, Lars; Holden, Marit; Liestøl, Knut; Clancy, Trevor; Drabløs, Finn; Ferkingstad, Egil; Johansen, Morten; Nygaard, Vegard; Tøstesen, Eivind; Frigessi, Arnoldo; Hovig, Eivind (2011). "The differential disease regulome". BMC Genomics. 12 (1): 353. doi:10.1186/1471-2164-12-353. PMC 3160420. PMID 21736759.