Thomas Humphrey may refer to:
- Tom Humphrey (American football) (born 1962), American football player
- Thomas Humphrey (cricketer), English cricketer
- Tom Humphrey (artist) (1858–1922), Scottish-born Australian artist
- T. C. Humphrey (Thomas Chauncey Humphrey), state legislator in Arkansas
- Thomas E. Humphrey (born 1945), Chief Justice of the Maine Superior Court
- Thomas M. Humphrey (born 1935), American economist
- Thomas Humphrey (MP) (c. 1554–1624), English politician
- A fictional character from the series Orange is the New Black