Thomas Keane may refer to:
- Tom Keane (1926–2001), American football cornerback
- Tom Keane, musician, see The Keane Brothers
- Rory Keane (Thomas Roderick Keane, 1922–2004), Irish footballer
- Tommy Keane (1968–2012), Irish footballer
- Thomas E. Keane (1905–1996), American politician
- Thomas P. Keane (1878–1945), American politician