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The throat-1 RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] The throat-1 motif has not yet (as of 2018) been found in a classified organism, but rather is known only from metagenomic sequences isolated from the human throat is, more rarely, tongue.
| throat-1 | |
|---|---|
 Consensus secondary structure and sequence conservation of throat-1 RNA | |
| Identifiers | |
| Symbol | throat-1 |
| Rfam | RF03110 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
Throat-1 RNAs are only known within metagenomic sequences, and these sequences often consist of short contigs that do not permit detailed analysis of nearby protein-coding genes. However, even with this technical limitation, it is apparent that throat-1 RNAs do not have a strong association with neighboring genes. Therefore, they likely function in trans as small RNAs.
References
edit- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.