Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene.[5][6]

THBS3
Identifiers
AliasesTHBS3, TSP3, thrombospondin 3
External IDsOMIM: 188062; MGI: 98739; HomoloGene: 5159; GeneCards: THBS3; OMA:THBS3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252607
NM_001252608
NM_007112

NM_013691

RefSeq (protein)

NP_001239536
NP_001239537
NP_009043

NP_038719

Location (UCSC)Chr 1: 155.2 – 155.21 MbChr 3: 89.12 – 89.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation.[7] This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1.[6] Identified as the gene on chromosome 1 responsible for mediating an associated with genetic susceptibility to SARS-CoV-2 infection.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169231Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028047Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vos HL, Devarayalu S, de Vries Y, Bornstein P (June 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". The Journal of Biological Chemistry. 267 (17): 12192–12196. doi:10.1016/S0021-9258(19)49823-2. PMID 1601886.
  6. ^ a b "Entrez Gene: THBS3 thrombospondin 3".
  7. ^ Hankenson KD, Hormuzdi SG, Meganck JA, Bornstein P (July 2005). "Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMC 1156967. PMID 15964815.
  8. ^ Niemi ME, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, et al. (December 2021). "Mapping the human genetic architecture of COVID-19". Nature. 600 (7889): 472–477. Bibcode:2021Natur.600..472C. doi:10.1038/s41586-021-03767-x. PMC 8674144. PMID 34237774. S2CID 235776838.

Further reading

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