Thrombospondin 4

Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene.

THBS4
Identifiers
Aliases	THBS4, TSP4, TSP-4, thrombospondin 4
External IDs	OMIM: 600715; MGI: 1101779; HomoloGene: 20691; GeneCards: THBS4; OMA:THBS4 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q14.1 Start 79,991,311 bp End 80,083,287 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 C3|13 47.75 cM Start 92,888,098 bp End 92,931,326 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon tendon of biceps brachii synovial joint pericardium synovial membrane glutes apex of heart tibial nerve body of tongue vena cava Top expressed in ankle left colon sciatic nerve lip body of femur soleus muscle intercostal muscle medial head of gastrocnemius muscle tibialis anterior muscle quadriceps femoris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding integrin binding protein binding growth factor activity calcium ion binding Cellular component basement membrane extracellular exosome extracellular region sarcoplasmic reticulum extracellular matrix endoplasmic reticulum extracellular space collagen-containing extracellular matrix Biological process myoblast migration positive regulation of endothelial cell proliferation endothelial cell-cell adhesion response to unfolded protein cell adhesion positive regulation of neutrophil chemotaxis positive regulation of peptidyl-tyrosine phosphorylation negative regulation of angiogenesis tissue remodeling positive regulation of cell division response to endoplasmic reticulum stress regulation of tissue remodeling behavioral response to pain regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7060 21828 Ensembl ENSG00000113296 ENSMUSG00000021702 UniProt P35443 Q9Z1T2 RefSeq (mRNA) NM_001306212 NM_001306213 NM_001306214 NM_003248 NM_011582 RefSeq (protein) NP_001293141 NP_001293142 NP_001293143 NP_003239 NP_035712 Location (UCSC) Chr 5: 79.99 – 80.08 Mb Chr 13: 92.89 – 92.93 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. This protein may be involved in local signaling in the developing and adult nervous system, in bone formation and fracture healing, and in osteoarthritis.

Further reading

• Arber S, Caroni P (1996). "Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth". J. Cell Biol. 131 (4): 1083–94. doi:10.1083/jcb.131.4.1083. PMC 2200004. PMID 7490284.
• Lawler J, Duquette M, Urry L, et al. (1993). "The evolution of the thrombospondin gene family". J. Mol. Evol. 36 (6): 509–16. Bibcode:1993JMolE..36..509L. doi:10.1007/BF00556355. PMID 8350346. S2CID 22473680.
• Lawler J, Duquette M, Whittaker CA, et al. (1993). "Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family". J. Cell Biol. 120 (4): 1059–67. doi:10.1083/jcb.120.4.1059. PMC 2200072. PMID 8432726.
• Newton G, Weremowicz S, Morton CC, et al. (2000). "The thrombospondin-4 gene". Mamm. Genome. 10 (10): 1010–6. doi:10.1007/s003359901149. PMID 10501972. S2CID 27379216.
• Carron JA, Hiscott P, Hagan S, et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4". Int. J. Biochem. Cell Biol. 32 (11–12): 1137–42. doi:10.1016/S1357-2725(00)00065-0. PMID 11137453.
• Luo J, Dunn T, Ewing C, et al. (2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". Prostate. 51 (3): 189–200. doi:10.1002/pros.10087. PMID 11967953. S2CID 42730702.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Congote LF, Difalco MR, Gibbs BF (2004). "The C-terminal peptide of thrombospondin-4 stimulates erythroid cell proliferation". Biochem. Biophys. Res. Commun. 324 (2): 673–8. doi:10.1016/j.bbrc.2004.09.107. PMID 15474480.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• van Doorn R, Zoutman WH, Dijkman R, et al. (2005). "Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73". J. Clin. Oncol. 23 (17): 3886–96. doi:10.1200/JCO.2005.11.353. PMID 15897551.
• Stenina OI, Ustinov V, Krukovets I, et al. (2006). "Polymorphisms A387P in thrombospondin-4 and N700S in thrombospondin-1 perturb calcium binding sites". FASEB J. 19 (13): 1893–5. doi:10.1096/fj.05-3712fje. PMID 16148025. S2CID 27097671.
• Misenheimer TM, Mosher DF (2006). "Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2". J. Biol. Chem. 280 (50): 41229–35. doi:10.1074/jbc.M504696200. PMC 2219889. PMID 16246837.
• Cui J, Randell E, Renouf J, et al. (2006). "Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population". Am. Heart J. 152 (3): 543.e1–5. doi:10.1016/j.ahj.2006.06.002. PMID 16923428.
• Cáceres M, Suwyn C, Maddox M, et al. (2007). "Increased cortical expression of two synaptogenic thrombospondins in human brain evolution". Cereb. Cortex. 17 (10): 2312–21. doi:10.1093/cercor/bhl140. PMID 17182969.