Tikhomirov (Russian: Тихомиров, female Tikhomirova (Тихомирова)) is a Russian surname, which may refer to:
- Aleksandr Tikhomirov - zoologist
- Alexander Tikhomirov - a Soviet army officer and Hero of the Soviet Union
- Dmitriy Tikhomirov - pedagogue
- Igor Tikhomirov - Soviet and Canadian fencer
- Igor Tikhomirov (musician) - Soviet and Russian jazz guitarist, member of the band Kino
- Ioasaf Tikhomirov (1872-1908) - a Russian actor and founder member of the Moscow Art Theatre
- Lev Tikhomirov - Russian revolutionary
- Mikhail Tikhomirov - Soviet paleographer
- Nikolai Tikhomirov - Russian engineer
- Nikolai Tikhomirov (chemical engineer) - Russian Soviet chemical engineer and rocket pioneer
- Vasily Tikhomirov - Russian and Soviet dancer and choreographer
- Viktor Tikhomirov - a Soviet scientist
- Vladimir Tikhomirov - a Soviet army officer and Hero of the Soviet Union
- Vladimir Tikhomirov - Soviet geologist
- Metropolitan Sergius (Tikhomirov) of Japan