Timelotem

Timelotem
Clinical data
ATC code	none;
Identifiers
	IUPAC name 10-fluoro-3-methyl-7-thiophen-2-yl-2,4,4a,5-tetrahydro-1H-pyrazino[1,2-a][1,4]benzodiazepine;
CAS Number	96306-34-2;
PubChem CID	65844;
CompTox Dashboard (EPA)	DTXSID90869269 ;
Chemical and physical data
Formula	C17H18FN3S
Molar mass	315.41 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCN2C(C1)CN=C(C3=C2C=C(C=C3)F)C4=CC=CS4;
	InChI InChI=1S/C17H18FN3S/c1-20-6-7-21-13(11-20)10-19-17(16-3-2-8-22-16)14-5-4-12(18)9-15(14)21/h2-5,8-9,13H,6-7,10-11H2,1H3; Key:ICHHTOMWWAMJQP-UHFFFAOYSA-N;

Timelotem is a benzodiazepine derivative with an unusual activity profile. Unlike most benzodiazepines, timelotem has little or no activity at the GABA_A receptor, but instead acts as an atypical antipsychotic drug with similar pharmacology and effects to the structurally related drug clozapine.^[1] It has two enantiomers, but has only been studied as the racemic mix.

References

^ Schmidt WJ, Krähling H, Ruhland M (October 1987). "Antagonism of AP-5- and amphetamine-induced behaviour by timelotem as compared with clozapine and haloperidol". Life Sciences. 41 (16): 1909–14. doi:10.1016/0024-3205(87)90742-9. PMID 2889124.

[Schmidt_1987-1] Schmidt WJ, Krähling H, Ruhland M (October 1987). "Antagonism of AP-5- and amphetamine-induced behaviour by timelotem as compared with clozapine and haloperidol". Life Sciences. 41 (16): 1909–14. doi:10.1016/0024-3205(87)90742-9. PMID 2889124.

[1]

Clinical data

ATC code	none
Identifiers
IUPAC name 10-fluoro-3-methyl-7-thiophen-2-yl-2,4,4a,5-tetrahydro-1H-pyrazino[1,2-a][1,4]benzodiazepine
CAS Number	96306-34-2
PubChem CID	65844
CompTox Dashboard (EPA)	DTXSID90869269
Chemical and physical data
Formula	C₁₇H₁₈FN₃S
Molar mass	315.41 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN1CCN2C(C1)CN=C(C3=C2C=C(C=C3)F)C4=CC=CS4
InChI InChI=1S/C17H18FN3S/c1-20-6-7-21-13(11-20)10-19-17(16-3-2-8-22-16)14-5-4-12(18)9-15(14)21/h2-5,8-9,13H,6-7,10-11H2,1H3 Key:ICHHTOMWWAMJQP-UHFFFAOYSA-N

Timelotem

See also

References