Tirucalladienol synthase (EC 5.4.99.56, PEN3) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, tirucalla-7,24-dien-3beta-ol-forming).[1] This enzyme catalyses the following chemical reaction
| Tirucalladienol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.4.99.56 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (3S)-2,3-epoxy-2,3-dihydrosqualene tirucalla-7,24-dien-3beta-ol
The product from Arabidopsis thaliana is tirucalla-7,24-dien-3beta-ol.
References
edit- ^ Morlacchi P, Wilson WK, Xiong Q, Bhaduri A, Sttivend D, Kolesnikova MD, Matsuda SP (June 2009). "Product profile of PEN3: the last unexamined oxidosqualene cyclase in Arabidopsis thaliana". Organic Letters. 11 (12): 2627–30. doi:10.1021/ol9005745. PMID 19445469.
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edit- Tirucalladienol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
