Tlaloc may refer to:
- Tláloc, the Aztec god of rain.
- Tláloc (Mexibús), a BRT station in Chimalhuacán.
- Cerro Tláloc, a mountain and archaeological site in central Mexico.
- Tlaloc (fish), a genus of fish.
- Tlaloc Rivas, a Mexican-American writer.
- Tlaloc, a fictional character from the Legends of Dune books.