Tom, Thomas or Tommy Keene may refer to:
- Tom Keene (actor) (1896–1963), American film actor
- Tom Keene (radio host) (born 1952), American radio host associated with Bloomberg Radio
- Tommy Keene (1958–2017), American singer-songwriter
- Thomas W. Keene (1840–1898), American stage actor
- Thomas Keen (runner) (born 2001), British athlete