Tooth regeneration is a stem cell based regenerative medicine procedure in the field of tissue engineering and stem cell biology to replace damaged or lost teeth by regrowing them from autologous stem cells.[1]
As a source of the new bioengineered teeth, somatic stem cells are collected and reprogrammed to induced pluripotent stem cells which can be placed in the dental lamina directly or placed in a reabsorbable biopolymer[2] in the shape of the new tooth.[3]
History
editYoung et al first demonstrated in 2002 that teeth could be regenerated from cells.[4]
The first clinical trial on tooth regeneration started in 2023 in Japan, for a medicine stimulating tooth regrowth by inhibition of USAG-1.[5][6][7]
Challenges
editThe majority of stem cell studies have stopped at the stage of animal studies and have not proceeded to clinical trials due to numerous safety and ethical concerns. The potential risks of undesired tissue formation, tumourigenesis, and metastasis has not yet been resolved.[8]
See also
edit
References
edit- ^ Otsu, Keishi; Kumakami-Sakano, Mika; Fujiwara, Naoki; Kikuchi, Kazuko; Keller, Laetitia; Lesot, Hervé; Harada, Hidemitsu (2014). "Stem cell sources for tooth regeneration: current status and future prospects". Frontiers in Physiology. 5: 36. doi:10.3389/fphys.2014.00036. PMC 3912331. PMID 24550845.
- ^ Kellomäki, Minna; Törmälä, Pertti (2003). "Processing of Resorbable Poly-α-Hydroxy Acids for Use as Tissue-Engineering Scaffolds". Biopolymer Methods in Tissue Engineering. Vol. 238. pp. 1–10. doi:10.1385/1-59259-428-X:1. ISBN 978-1-59259-428-3.
- ^ Hill, David J. (10 May 2012). "Toothless No More - Researchers Using Stem Cells to Grow New Teeth". Singularity Hub.
- ^ Young, C.S.; Terada, S.; Vacanti, J.P.; Honda, M.; Bartlett, J.D.; Yelick, P.C. (October 2002). "Tissue Engineering of Complex Tooth Structures on Biodegradable Polymer Scaffolds". Journal of Dental Research. 81 (10): 695–700. doi:10.1177/154405910208101008. PMID 12351668.
- ^ "World's 1st 'tooth regrowth' medicine moves toward clinical trials in Japan". Mainichi. 12 June 2023.
- ^ Murashima-Suginami A, Kiso H, Tokita Y, Mihara E, Nambu Y, Uozumi R, Tabata Y, Bessho K, Takagi J, Sugai M, Takahashi K (February 2021). "Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling". Science Advances. 7 (7). doi:10.1126/sciadv.abf1798. PMC 7880588. PMID 33579703.
- ^ Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K, Takagi J, Sugai M, Tabata Y, Takahashi K (March 2023). "Advances in tooth agenesis and tooth regeneration". Regenerative Therapy. 22: 160–168. doi:10.1016/j.reth.2023.01.004. PMC 9931762. PMID 36819612.
- ^ Thalakiriyawa, Dineshi Sewvandi; Dissanayaka, Waruna Lakmal (February 2024). "Advances in Regenerative Dentistry Approaches: An Update". International Dental Journal. 74 (1): 25–34. doi:10.1016/j.identj.2023.07.008. PMC 10829373. PMID 37541918.
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