Topografov virus is an enveloped, negative-sense RNA virus of the genus Orthohantavirus in the Bunyavirales order. It is the first hantavirus to be isolated from Siberian lemmings (Lemmus sibiricus) found near the Topografov River in the Taymyr Peninsula, Siberia.[1][2]
| Topografov virus | |
|---|---|
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Negarnaviricota |
| Class: | Ellioviricetes |
| Order: | Bunyavirales |
| Family: | Hantaviridae |
| Genus: | Orthohantavirus |
| Species: | |
| Virus: | Topografov virus
|
Virology
editHantaviruses have been shown to evolve with their hosts. Phylogenetic analysis demonstrates that Topografov virus is related to Khabarovsk virus and Puumala virus. This close relationship is believed to be due to a rodent host switch that took place at some point their respective evolutions. [3] Topografov virus and Khabarovsk virus are believed to have a common ancestor, possibly from a Microtus species that lived over 1 million years ago.[4][5]
This host switch has been known to occur only once before in white-footed mice (Peromyscus leucopus) in North America.[6][7]
See also
editReferences
edit- ^ Plyusnin A, Vapalahti O, Lundkvist Å, Henttonen H, Vaheri A. Newly recognized hantavirus in Siberian lemmings. Lancet. 1996;347:1835–1836.
- ^ Olli Vapalahti., Åke Lundkvist, Vadim Fedorov, et al. Isolation and Characterization of a Hantavirus from Lemmus sibiricus: Evidence for Host Switch during Hantavirus Evolution. J Virol. 1999 July; 73(7): 5586–5592
- ^ Plyusnin A, Vapalahti O, Vaheri A. Hantaviruses: genome structure, expression and evolution. J Gen Virol. 1996;77:2677–2687.
- ^ Modi W S. Phylogenetic history of LINE-1 among arvicolid rodents. Mol Biol Evol. 1996;13:633–641.
- ^ Van Regenmortel M H V, Bishop D H L, Fauquet C M, Mayo M A, Maniloff J, Calisher C H. Guidelines to the demarcation of virus species. Arch Virol. 1997;142:1505–1528.
- ^ Morzunov S P, Rowe J E, Ksiazek T G, Peters C J, St. Jeor S C, Nichol S T. Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America. J Virol. 1998;72:57–64.
- ^ Plyusnin A, Vapalahti O, Vaheri A. Hantaviruses: genome structure, expression and evolution. J Gen Virol. 1996;77:2677–2687.