Trans-endocytosis is the biological process where material created in one cell undergoes endocytosis (enters) into another cell. If the material is large enough, this can be observed using an electron microscope.[1] Trans-endocytosis from neurons to glia has been observed using time-lapse microscopy.[2]
Trans-endocytosis also applies to molecules. For example, this process is involved when a part of the protein Notch is cleaved off and undergoes endocytosis into its neighboring cell.[3][4] Without Notch trans-endocytosis, there would be too many neurons in a developing embryo.[5] Trans-endocytosis is also involved in cell movement when the protein ephrin is bound by its receptor from a neighboring cell.[6]
References
edit- ^ Spacek J; Harris K. (April 2004). "Trans-endocytosis via spinules in adult rat hippocampus". J. Neurosci. 24 (17): 4233–4241. doi:10.1523/JNEUROSCI.0287-04.2004. PMC 6729277. PMID 15115819.
- ^ Lauterbach J; Klein R. (November 2006). "Release of full-length EphB2 receptors from hippocampal neurons to cocultured glial cells". J. Neurosci. 26 (45): 11575–11581. doi:10.1523/JNEUROSCI.2697-06.2006. PMC 6674799. PMID 17093078.
- ^ Krämer H. (April 2000). "RIPping notch apart: a new role for endocytosis in signal transduction?". Sci STKE. 2000 (29): 1pe–1. doi:10.1126/stke.2000.29.pe1. PMID 11752592. S2CID 33395895.
- ^ Parks AL; Klueg KM; Stout JR; Muskavitch MA. (April 2000). "Ligand endocytosis drives receptor dissociation and activation in the Notch pathway". Development. 127 (7): 1373–1385. doi:10.1242/dev.127.7.1373. PMID 10704384.
- ^ Klueg KM; Muskavitch MA. (October 1999). "Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila". J Cell Sci. 112 (19): 3289–3297. doi:10.1242/jcs.112.19.3289. PMID 10504334.
- ^ Marston DJ; Dickinson S; Nobes CD. (October 2003). "Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion". Nat. Cell Biol. 5 (10): 879–888. doi:10.1038/ncb1044. PMID 12973357. S2CID 24717812.
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