Trans-resveratrol di-O-methyltransferase (EC 2.1.1.240, ROMT, resveratrol O-methyltransferase, pterostilbene synthase) is an enzyme with systematic name S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase.[1] This enzyme catalyses the following chemical reaction
| Trans-resveratrol di-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.240 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 2 S-adenosyl-L-methionine + trans-resveratrol 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction)
- (1a) S-adenosyl-L-methionine + trans-resveratrol S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene
- (1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene S-adenosyl-L-homocysteine + pterostilbene
The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.
References
edit- ^ Schmidlin L, Poutaraud A, Claudel P, Mestre P, Prado E, Santos-Rosa M, Wiedemann-Merdinoglu S, Karst F, Merdinoglu D, Hugueney P (November 2008). "A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine". Plant Physiology. 148 (3): 1630–9. doi:10.1104/pp.108.126003. PMC 2577258. PMID 18799660.
External links
edit- Trans-resveratrol+di-O-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
