Trichosporon asahii is a non-Candida yeast that has been reported to cause infections in immunocompromised patients.[2] T. asahii is the most prominent human pathogen in its genus, causing more than half of all Trichosporon infections. First discovered and named in 1929,[3] The currently accepted nomenclature of T. asahii was validated in 1994.[4]
| Trichosporon asahii | |
|---|---|
| |
| Gram stain of T. asahii | |
Scientific classification 
| |
| Domain: | Eukaryota |
| Kingdom: | Fungi |
| Division: | Basidiomycota |
| Class: | Tremellomycetes |
| Order: | Trichosporonales |
| Family: | Trichosporonaceae |
| Genus: | Trichosporon |
| Species: | T. asahii
|
| Binomial name | |
| Trichosporon asahii Akagi ex Sugita, A.Nishikawa & Shinoda[1]
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Disease
editThe clinical manifestations of T. asahii infection are non-specific and vary depending on the site of infection. The most common types of infection were urinary tract infections, fungemia, and disseminated infection.[2] Cutaneous infections have also been reported.[5]
Identification and culture
editT. asahii grows readily on routine laboratory media, producing white, yellow, or cream, yeast-like colonies on Sabouraud dextrose agar.[6] This fungus has a rapid growth rate and colonies mature in 5 days. When grown on cornmeal-Tween 80 agar, true hyphae, pseudohyphae, and blastoconidia can be seen under microscopic examination. Arthroconidia can be observed in older cultures. This fungus is able to hydrolyze urea through the production of urease.[6]
Treatment
editESCMID/ECMM guidelines recommend the use of voriconazole for the treatment of invasive T. asahii infections.[7] Patients have also been treated with amphotericin B and triazole therapy.[2]
References
edit- ^ "Trichosporon asahii". Global Biodiversity Information Facility.
- ^ a b c Li, Haitao; Guo, Meihong; Wang, Congmin; Li, Yibo; Fernandez, Anne Marie; Ferraro, Thomas N.; Yang, Rongya; Chen, Yong (2020). "Epidemiological study of Trichosporon asahii infections over the past 23 years". Epidemiology and Infection. 148: e169. doi:10.1017/S0950268820001624. ISSN 0950-2688. PMC 7439294. PMID 32703332.
- ^ Akagi, S (1929). "Uber eine neue mykotische Hautkrankheit". Jpn J Dermatol Urol. 29: 53–55.
- ^ Sugita, T; Nishikawa, A; Shinoda, T (Mar 1994). "Reclassification of Trichosporon cutaneum by DNA Relatedness By the Spectrophotometric Method and the Chemiluminometric Method". The Journal of General and Applied Microbiology. 40 (5): 397–408. doi:10.2323/jgam.40.397.
- ^ Schnur, Jack; Hawco, Colton; Fonarov, Ilya; Casadesus, Damian (Jun 2021). "Rare cutaneous manifestation of Trichosporon asahii". BMJ Case Reports. 14 (6): e243659. doi:10.1136/bcr-2021-243659. ISSN 1757-790X. PMC 8212178. PMID 34140332.
- ^ a b Sciortino, Carmen V. (2017). Atlas of clinically important fungi. Hoboken, New Jersey: John Wiley & Sons, Inc. pp. 58–59. ISBN 978-1-119-06966-9.
- ^ Arendrup, M.C.; Boekhout, T.; Akova, M.; Meis, J.F.; Cornely, O.A.; Lortholary, O. (Apr 2014). "ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections". Clinical Microbiology and Infection. 20: 76–98. doi:10.1111/1469-0691.12360. PMID 24102785.