Triclofos

Triclofos
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N05CM07 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances);
Identifiers
	IUPAC name 2,2,2-trichloroethanol dihydrogen phosphate;
CAS Number	306-52-5 8060-81-9;
PubChem CID	5563;
ChemSpider	5362 ;
UNII	J712EO9048;
KEGG	C07165;
ChEMBL	ChEMBL1201317 ;
CompTox Dashboard (EPA)	DTXSID9023700 ;
ECHA InfoCard	100.005.624
Chemical and physical data
Formula	C2H4Cl3O4P
Molar mass	229.37 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClC(Cl)(Cl)COP(=O)(O)O;
	InChI InChI=1S/C2H4Cl3O4P/c3-2(4,5)1-9-10(6,7)8/h1H2,(H2,6,7,8) ; Key:YYQRGCZGSFRBAM-UHFFFAOYSA-N ;
	(what is this?) (verify)

Triclofos is a sedative drug used rarely for treating insomnia.^[2]

Triclofos is a prodrug which is metabolised in the liver into the active drug trichloroethanol. The half-life of triclofos is fairly long and it may cause drowsiness the next day. Trichloroethanol may cause liver damage and triclofos should not be used for extended periods.

Triclofos is no longer available in the United States.^[3]

Side effects

Side effects may include:

References

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Erhorn S (2007). "Triclofos". xPharm: The Comprehensive Pharmacology Reference. Elsevier. pp. 1–4. doi:10.1016/B978-008055232-3.62797-7. ISBN 978-0-08-055232-3. Retrieved 29 February 2020.
^ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved 29 February 2020.

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[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] Erhorn S (2007). "Triclofos". xPharm: The Comprehensive Pharmacology Reference. Elsevier. pp. 1–4. doi:10.1016/B978-008055232-3.62797-7. ISBN 978-0-08-055232-3. Retrieved 29 February 2020.

[3] "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Retrieved 29 February 2020.

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