Tryptophan 2-C-methyltransferase

In enzymology, a tryptophan 2-C-methyltransferase (EC 2.1.1.106) is an enzyme that catalyzes the chemical reaction

tryptophan 2-C-methyltransferase
Identifiers
EC no.2.1.1.106
CAS no.126626-83-3
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
S-adenosyl-L-methionine + L-tryptophan S-adenosyl-L-homocysteine + L-2-methyltryptophan

Thus, the two substrates of this enzyme are S-adenosyl methionine and L-tryptophan, whereas its two products are S-adenosylhomocysteine and L-2-methyltryptophan.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase. Other names in common use include tryptophan 2-methyltransferase, and S-adenosylmethionine:tryptophan 2-methyltransferase.

References

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  • Frenzel T, Zhou P, Floss HG (1990). "Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferase". Arch. Biochem. Biophys. 278 (1): 35–40. doi:10.1016/0003-9861(90)90227-P. PMID 2321967.