Tubulin beta-4B chain formerly known as tubulin beta-2C chain is a protein that in humans is encoded by the TUBB4B gene.[5][6] It is thought that this protein could determine which hand is dominant in humans due to variations of the TUBB4B gene, which cause the protein to form microtubules that form cilia which direct fluids asymmetrically during development.[7]

TUBB4B
Identifiers
AliasesTUBB4B, Beta2, TUBB2, TUBB2C, tubulin beta 4B class IVb, LCAEOD
External IDsOMIM: 602660; MGI: 1915472; HomoloGene: 68504; GeneCards: TUBB4B; OMA:TUBB4B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006088

NM_146116

RefSeq (protein)

NP_006079

NP_666228

Location (UCSC)Chr 9: 137.24 – 137.24 MbChr 2: 25.11 – 25.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188229Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036752Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lewis SA, Gilmartin ME, Hall JL, Cowan NJ (Jul 1985). "Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype". J Mol Biol. 182 (1): 11–20. doi:10.1016/0022-2836(85)90023-3. PMID 3999141.
  6. ^ "Entrez Gene: TUBB2C tubulin, beta 2C".
  7. ^ Kulkarni, Sumeet (2024-04-02). "Right- or left-handed? Protein in embryo cells might help decide". Nature. doi:10.1038/d41586-024-00977-x.

Further reading

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