Tuftelin

TUFT1
Identifiers
Aliases	TUFT1, entrez:7286, tuftelin 1
External IDs	OMIM: 600087; MGI: 109572; HomoloGene: 7985; GeneCards: TUFT1; OMA:TUFT1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,583,583 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	94,566,179 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; pancreatic ductal cell; ; skin of thigh; ; hair follicle; ; skin of arm; ; skin of hip; ; gingival epithelium; ; skin of abdomen; ; buccal mucosa cell; ; human penis;
	Top expressed in
	lip; ; skin of external ear; ; esophagus; ; retinal pigment epithelium; ; epidermis; ; hair follicle; ; gastrula; ; corneal stroma; ; decidua; ; skin of back;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of tooth enamel; protein binding;
Cellular component	cytoplasm; extracellular region; intracellular anatomical structure;
Biological process	biomineral tissue development; bone mineralization; odontogenesis; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7286
	22156
	ENSG00000143367
	ENSMUSG00000005968
	Q9NNX1
	O08970
	NM_001126337; NM_001301317; NM_020127
	NM_011656; NM_001293728
	NP_001119809; NP_001288246; NP_064512
	NP_001280657; NP_035786
	Wikidata
View/Edit Human	View/Edit Mouse

Tuftelin is an acidic phosphorylated glycoprotein found in tooth enamel. In humans, the tuftelin protein is encoded by the TUFT1 gene.^[5]^[6] It is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation.^[7]

Classification

There are two kinds of enamel proteins: amelogenins and nonamelogenins. Tuftelin falls under nonamelogenins.^[8]

Function

This protein is formed for a short time during amelogenesis. The function of tuftelins is under contention, but it is proposed that it acts to start the mineralization process of enamel during tooth development.^[9]^[10]

Other significant proteins in enamel are amelogenins, enamelins, and ameloblastins.

Research

The human encoding gene for tuftelin (TUFT1) was cloned by Profs. Danny Deutsch and Aharon Palmon from the Hebrew University-Hadassah School of Dental Medicine in Jerusalem.^[6]

Interactions

Tuftelin has been shown to interact with TFIP11.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143367 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005968 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: TUFT1 tuftelin 1".
^ ^a ^b Deutsch D, Palmon A, Young MF, Selig S, Kearns WG, Fisher LW (July 1994). "Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization". Mamm. Genome. 5 (7): 461–2. doi:10.1007/BF00357011. PMID 7919663. S2CID 20041600.
^ "TUFT1 tuftelin 1 [Homo sapiens (human)] - Gene - NCBI". ncbi.nlm.nih.gov. Retrieved 2018-03-05.
^ Nanci, Antonio (2017-08-15). Ten Cate's Oral Histology - E-Book: Development, Structure, and Function. Elsevier Health Sciences. ISBN 9780323485180.
^ Deutsch D (June 1989). "Structure and function of enamel gene products". Anat. Rec. 224 (2): 189–210. doi:10.1002/ar.1092240209. PMID 2672884. S2CID 37887565.
^ Deutsch D, Palmon A, Fisher LW, Kolodny N, Termine JD, Young MF (August 1991). "Sequencing of bovine enamelin ("tuftelin") a novel acidic enamel protein". J. Biol. Chem. 266 (24): 16021–8. doi:10.1016/S0021-9258(18)98510-8. PMID 1874744.
^ Paine, C T; Paine M L; Luo W; Okamoto C T; Lyngstadaas S P; Snead M L (July 2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. 275 (29). UNITED STATES: 22284–92. doi:10.1074/jbc.M000118200. ISSN 0021-9258. PMID 10806191.

Deutsch D, Leiser Y, Shay B, et al. (2003). "The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues". Connect. Tissue Res. 43 (2–3): 425–34. doi:10.1080/03008200290001186. PMID 12489194. S2CID 12764804.
Deutsch D, Palmon A, Young MF, et al. (1994). "Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization". Mamm. Genome. 5 (7): 461–2. doi:10.1007/BF00357011. PMID 7919663. S2CID 20041600.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Paine CT, Paine ML, Luo W, et al. (2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. 275 (29): 22284–92. doi:10.1074/jbc.M000118200. PMID 10806191.
Bashir MM, Abrams WR, Tucker T, et al. (2000). "Molecular cloning and characterization of the bovine and human tuftelin genes". Connect. Tissue Res. 39 (1–3): 13–24, discussion 63–7. doi:10.3109/03008209809023908. PMID 11062985.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Mao Z, Shay B, Hekmati M, et al. (2002). "The human tuftelin gene: cloning and characterization". Gene. 279 (2): 181–96. doi:10.1016/S0378-1119(01)00749-1. PMID 11733143.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143367 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005968 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TUFT1 tuftelin 1".

[pmid7919663-6] Deutsch D, Palmon A, Young MF, Selig S, Kearns WG, Fisher LW (July 1994). "Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization". Mamm. Genome. 5 (7): 461–2. doi:10.1007/BF00357011. PMID 7919663. S2CID 20041600.

[7] "TUFT1 tuftelin 1 [Homo sapiens (human)] - Gene - NCBI". ncbi.nlm.nih.gov. Retrieved 2018-03-05.

[8] Nanci, Antonio (2017-08-15). Ten Cate's Oral Histology - E-Book: Development, Structure, and Function. Elsevier Health Sciences. ISBN 9780323485180.

[pmid2672884-9] Deutsch D (June 1989). "Structure and function of enamel gene products". Anat. Rec. 224 (2): 189–210. doi:10.1002/ar.1092240209. PMID 2672884. S2CID 37887565.

[pmid1874744-10] Deutsch D, Palmon A, Fisher LW, Kolodny N, Termine JD, Young MF (August 1991). "Sequencing of bovine enamelin ("tuftelin") a novel acidic enamel protein". J. Biol. Chem. 266 (24): 16021–8. doi:10.1016/S0021-9258(18)98510-8. PMID 1874744.

[pmid10806191-11] Paine, C T; Paine M L; Luo W; Okamoto C T; Lyngstadaas S P; Snead M L (July 2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. 275 (29). UNITED STATES: 22284–92. doi:10.1074/jbc.M000118200. ISSN 0021-9258. PMID 10806191.

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