Tyendinaga is an alternate spelling of Thayendanegea, an eighteenth-century Mohawk chief also known as Joseph Brant.
Tyendinaga may also refer to:
- Tyendinaga Mohawk Territory, a First Nations reserve on the Bay of Quinte
- Mohawks of the Bay of Quinte First Nation, the First Nation government that governs that reserve
- Tyendinaga (Mohawk) Airport, located on that reserve
- Tyendinaga, Ontario, a township in Ontario