U6atac minor spliceosomal RNA is a non-coding RNA which is an essential component of the minor U12-type spliceosome complex. The U12-type spliceosome is required for removal of the rarer class of eukaryotic introns (AT-AC, U12-type).[1]
| U6atac minor spliceosomal RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of U6atac | |
| Identifiers | |
| Symbol | U6atac |
| Rfam | RF00619 |
| Other data | |
| RNA type | Gene; snRNA; splicing |
| Domain(s) | Eukaryota |
| GO | GO:0000355 GO:0000369 GO:0030622 GO:0030627 GO:0005691 |
| SO | SO:0000274 |
| PDB structures | PDBe |
U6atac snRNA is proposed to form a base-paired complex with another spliceosomal RNA U4atac via two stem loop regions. These interacting stem loops have been shown to be required for in vivo splicing.[2] U6atac is the functional analog of U6 spliceosomal RNA in the major U2-type spliceosomal complex.[2]
References
edit- ^ Lorkovic ZJ, Lehner R, Forstner C, Barta A (2005). "Evolutionary conservation of minor U12-type spliceosome between plants and humans". RNA. 11 (7): 1095–1107. doi:10.1261/rna.2440305. PMC 1370794. PMID 15987817.
- ^ a b Padgett RA, Shukla GC (2002). "A revised model for U4atac/U6atac snRNA base pairing". RNA. 8 (2): 125–128. doi:10.1017/S1355838202017156. PMC 1370236. PMID 11911359.
- Shukla GC, Padgett RA (1999). "Conservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plants". RNA. 5 (4): 525–538. doi:10.1017/S1355838299982213. PMC 1369779. PMID 10199569.
External links
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