Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene.[5][6][7]

UBE2G2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBE2G2, UBC7, ubiquitin conjugating enzyme E2 G2
External IDsOMIM: 603124; MGI: 1343188; HomoloGene: 6599; GeneCards: UBE2G2; OMA:UBE2G2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182688
NM_001202489
NM_003343

NM_019803

RefSeq (protein)

NP_001189418
NP_003334
NP_872630

NP_062777

Location (UCSC)Chr 21: 44.77 – 44.8 MbChr 10: 77.46 – 77.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[7] Ube2g2 is known to interact with a variety of other proteins, including ubiquitin, the AMFR (E3 gp78), and the SYVN1 (Hrd1 RING).

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184787Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009293Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katsanis N, Fisher EM (Sep 1998). "Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene". Genomics. 51 (1): 128–31. doi:10.1006/geno.1998.5263. PMID 9693041.
  6. ^ Rose SA, Leek JP, Moynihan TP, Ardley HC, Markham AF, Robinson PA (Mar 1999). "Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to human chromosome band 21q22.3 by in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 98–9. doi:10.1159/000015141. PMID 9925943. S2CID 13129608.
  7. ^ a b "Entrez Gene: UBE2G2 ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)".

Further reading

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  • Overview of all the structural information available in the PDB for UniProt: P60604 (Ubiquitin-conjugating enzyme E2 G2) at the PDBe-KB.