UBE4A

Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.

UBE4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WGM
Identifiers
Aliases	UBE4A, E4, UBOX2, UFD2, ubiquitination factor E4A, NEDHMS
External IDs	OMIM: 603753; MGI: 2154580; HomoloGene: 3517; GeneCards: UBE4A; OMA:UBE4A - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 118,359,600 bp End 118,399,211 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.2 Start 44,834,425 bp End 44,876,898 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus visceral pleura parietal pleura pons skin of thigh trigeminal ganglion superior vestibular nucleus inferior ganglion of vagus nerve Top expressed in muscle of thigh neural layer of retina genital tubercle spermatocyte ganglion of vagus nerve granulocyte zygote tail of embryo yolk sac ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding transferase activity ubiquitin-ubiquitin ligase activity Cellular component ubiquitin ligase complex nucleus cytoplasm Biological process protein ubiquitination ubiquitin-dependent protein catabolic process ubiquitin-dependent ERAD pathway protein polyubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9354 140630 Ensembl ENSG00000110344 ENSMUSG00000059890 UniProt Q14139 E9Q735 RefSeq (mRNA) NM_004788 NM_001204077 NM_145400 NM_001346698 NM_001361075 NM_001361076 RefSeq (protein) NP_001191006 NP_004779 NP_001333627 NP_663375 NP_001348004 NP_001348005 Location (UCSC) Chr 11: 118.36 – 118.4 Mb Chr 9: 44.83 – 44.88 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.

Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly.

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Mahoney JA, Odin JA, White SM, et al. (2002). "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis". Biochem. J. 361 (Pt 3): 587–95. doi:10.1042/0264-6021:3610587. PMC 1222341. PMID 11802788.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Contino G, Amati F, Pucci S, et al. (2004). "Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues". Gene. 328: 69–74. doi:10.1016/j.gene.2003.11.017. PMID 15019985.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Spinette S, Lengauer C, Mahoney JA, et al. (2006). "Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation". Cell Cycle. 3 (12): 1638–44. doi:10.4161/cc.3.12.1345. PMID 15611659.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.