Mitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene.[5]

UCP2
Identifiers
AliasesUCP2, BMIQ4, SLC25A8, UCPH, uncoupling protein 2
External IDsOMIM: 601693; MGI: 109354; HomoloGene: 2516; GeneCards: UCP2; OMA:UCP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003355

NM_011671

RefSeq (protein)

NP_035801

Location (UCSC)Chr 11: 73.97 – 73.98 MbChr 7: 100.14 – 100.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate, or uncouple, oxidative phosphorylation from ATP synthesis by dissipating the mitochondrial membrane potential as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells, which reduces production of reactive oxygen species (ROS).

In contrast to UCP1 and UCP3, which are primarily expressed in adipose and smooth muscle, UCP2 is expressed on many different tissues[6] including the kidney, liver, GI tract, brain, and skeletal muscle.

The exact mechanisms of anion transfer by UCPs are not known.[7] UCPs contain the three homologous protein domains of MACPs. Although it was originally thought to play a role in non-shivering thermogenesis, obesity, diabetes and atherosclerosis, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species.[8]

Chromosomal order is 5'-UCP3-UCP2-3'.[9]

Mitochondrial Uncoupling Protein 2

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175567Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033685Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB (Jul 1997). "UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue". Biochem Biophys Res Commun. 235 (1): 79–82. doi:10.1006/bbrc.1997.6740. PMID 9196039.
  6. ^ "Tissue expression of UCP2 - Summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2020-08-20.
  7. ^ Garlid, Keith D.; Jabůrek, Martin; Ježek, Petr; Vařecha, Miroslav (2000-08-15). "How do uncoupling proteins uncouple?". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1459 (2–3): 383–389. doi:10.1016/S0005-2728(00)00175-4. ISSN 0005-2728. PMID 11004454.
  8. ^ Arsenijevic D, Onuma H, Pecqueur C, et al. (December 2000). "Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production". Nat. Genet. 26 (4): 435–9. doi:10.1038/82565. PMID 11101840. S2CID 29831657.
  9. ^ "Entrez Gene: UCP2 uncoupling protein 2 (mitochondrial, proton carrier)".

Further reading

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