UDP-glucuronate 4-epimerase

In enzymology, an UDP-glucuronate 4-epimerase (EC 5.1.3.6) is an enzyme that catalyzes the chemical reaction

UDP-glucuronate 4-epimerase
Identifiers
EC no.5.1.3.6
CAS no.9024-17-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
UDP-glucuronate UDP-D-galacturonate

Hence, this enzyme has one substrate, UDP-glucuronate, and one product, UDP-D-galacturonate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-glucuronate 4-epimerase. Other names in common use include uridine diphospho-D-galacturonic acid, UDP glucuronic epimerase, uridine diphosphoglucuronic epimerase, UDP-galacturonate 4-epimerase, uridine diphosphoglucuronate epimerase, and UDP-D-galacturonic acid 4-epimerase. This enzyme participates in starch and sucrose metabolism and nucleotide sugars metabolism.

References

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  • FEINGOLD DS, NEUFELD EF, HASSID WZ (1960). "The 4-epimerization and decarboxylation of uridine diphosphate D-glucuronic acid by extracts from Phaseolus aureus seedlings". J. Biol. Chem. 235 (4): 910–3. doi:10.1016/S0021-9258(18)69449-9. PMID 13821949.