UGT1A8

UGT1A8
Identifiers
Aliases	UGT1A8, UDPGT, UDPGT 1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H, UDP glucuronosyltransferase family 1 member A8, UGT1-01, UGT-1A, UGT1.1, UGT1A, hUG-BR1, UGT1, GNT1, UGT1A1, UDPGT 1-1
External IDs	OMIM: 606433; MGI: 3576092; HomoloGene: 133281; GeneCards: UGT1A8; OMA:UGT1A8 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,773,300 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,146,719 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; gallbladder; ; olfactory zone of nasal mucosa; ; duodenum; ; urinary bladder; ; epithelium of colon; ; right lobe of liver; ; islet of Langerhans; ; appendix;
	Top expressed in
	hepatobiliary system; ; liver; ; duodenum; ; embryo; ; colon; ; renal cortex; ; proximal tubule; ; stomach; ; human kidney; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; enzyme inhibitor activity; retinoic acid binding; hexosyltransferase activity; protein homodimerization activity; glycosyltransferase activity; glucuronosyltransferase activity; fatty acid binding; steroid binding; protein heterodimerization activity; enzyme binding; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	steroid metabolic process; coumarin metabolic process; negative regulation of steroid metabolic process; retinoic acid metabolic process; negative regulation of cellular glucuronidation; fatty acid metabolic process; cellular glucuronidation; flavonoid glucuronidation; xenobiotic glucuronidation; flavone metabolic process; metabolism; negative regulation of glucuronosyltransferase activity; negative regulation of fatty acid metabolic process; negative regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	54576
	394434
	ENSG00000242366
	ENSMUSG00000090175
	Q9HAW9
	Q62452
	NM_019076
	NM_201644
	NP_061949
	NP_964006
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 1-8 is an enzyme that in humans is encoded by the UGT1A8 gene.^[5]^[6]^[7]

Function

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000242366 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090175 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (Mar 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J Biol Chem. 267 (5): 3257–61. doi:10.1016/S0021-9258(19)50724-4. PMID 1339448.
^ Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH (June 2002). "Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3". Pharmacogenetics. 12 (4): 287–97. doi:10.1097/00008571-200206000-00004. PMID 12042666.
^ "Entrez Gene: UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000242366 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090175 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1339448-5] Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (Mar 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J Biol Chem. 267 (5): 3257–61. doi:10.1016/S0021-9258(19)50724-4. PMID 1339448.

[pmid12042666-6] Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH (June 2002). "Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3". Pharmacogenetics. 12 (4): 287–97. doi:10.1097/00008571-200206000-00004. PMID 12042666.

[entrez-7] "Entrez Gene: UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8".

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