(S)-UH-301 is a drug and research chemical widely used in scientific studies. It acts as a selective 5-HT1A receptor silent antagonist.[1] It is structurally related to 8-OH-DPAT.[1] UH-301 was found to produce a head-twitch response in mice which is usually typical of 5-HT2A agonist drugs, and has subsequently been used to investigate how 5-HT1A receptor activity modulates 5-HT2A receptors downstream.[2]
 | |
 | |
| Identifiers | |
|---|---|
| |
| CAS Number | |
| IUPHAR/BPS | |
| UNII | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C16H24FNO |
| Molar mass | 265.372 g·mol−1 |
| 3D model (JSmol) | |
| |
| (verify) | |
See also
editReferences
edit- ^ a b Björk L, Cornfield LJ, Nelson DL, Hillver SE, Andén NE, Lewander T, Hacksell U (July 1991). "Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects". The Journal of Pharmacology and Experimental Therapeutics. 258 (1): 58–65. PMID 1830099.
- ^ Darmani NA, Reeves SL (September 1996). "The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice". Pharmacology, Biochemistry, and Behavior. 55 (1): 1–10. doi:10.1016/0091-3057(96)00072-X. PMID 8870031. S2CID 25607128.
 | This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |